Evidence map›Paper›PMID 33984119›Full record

ArticleJournal of vision2021

How chromatic cues can guide human eye growth to achieve good focus.

Timothy J Gawne, Rafael Grytz, Thomas T Norton

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of vision, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06598423 (Pilot Test of a Novel Wavelength-Based Method to Control Childhood Myopia), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06598423 narecruitingnot on this mapstarted 2025, after this paper: background citation

Pilot Test of a Novel Wavelength-Based Method to Control Childhood Myopia

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2025 to 2027Enrolled80ConditionsMyopiaArmsSpecialized soft contact lens 1, Specialized soft contact lens 2
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026
    Article
  3. Review
  4. Review
  5. S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Optical and Visual Diet in Myopia.Investigative ophthalmology & visual science · 2025
    Review
  10. Article
  11. Article
  12. Refractive development II: Modelling normal and myopic eye growth.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. IMI 2023 Digest.Investigative ophthalmology & visual science · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Timothy J GawneDepartment of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Rafael GrytzDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Thomas T NortonDepartment of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Rafael Advanced Defense Systems (Israel) · ILUniversity of Alabama at Birmingham · USUtah AIDS Foundation · US

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026
$16.9M
Effects of wavelength on achieving and maintaining emmetropiaR01EY028578 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAWNE, TIMOTHY J · 2018 to 2022
$1.9M
Myopia and the Visual EnvironmentR01EY036970 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIMOTHY J GAWNE · 2025 to 2026
$989k
Control of refractive development with temporally modulated lightR21EY025254 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAWNE, TIMOTHY J · 2016 to 2017
$404k
NEI NIH HHS R01 EY028578NEI NIH HHS R01 EY036970NEI NIH HHS R21 EY025254
6 · The paper itself

Abstract

The postnatal growing eye uses visual cues to actively control its own axial elongation to achieve and maintain sharp focus, a process termed emmetropization. The primary visual cue may be the difference in image sharpness as sensed by the arrays of short- and long-wavelength sensitive cone photoreceptors caused by longitudinal chromatic aberration: Shorter wavelengths focus in front of longer wavelengths. However, the sparse distribution of short-wavelength sensitive cones across the retina suggests that they do not have sufficient spatial sampling resolution for this task. Here, we show that the spacing of the short-wavelength sensitive cones in humans is sufficient for them, in conjunction with the longer wavelength cones, to use chromatic signals to detect defocus and guide emmetropization. We hypothesize that the retinal spacing of the short-wavelength sensitive cones in many mammalian species is an evolutionarily ancient adaption that allows the efficient use of chromatic cues in emmetropization.

Indexed as

CuesRefraction, OcularAnimalsHumansRetinaRetinal Cone Photoreceptor Cells

Identifiers

PMID33984119
PMCPMC8131997
OpenAlexW3161134013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.