SynthesisPloS one2021
Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The Landscape of Products for Diabetic Peripheral Neuropathy: A Scientific and Patent Systematic Review.Recent patents on biotechnology · 2025Pooled it
- In-hospital unfavorable outcomes of MIS-C during 2020-2022: a systematic review.European journal of pediatrics · 2024Pooled it
- The prevalence of peripheral neuropathy among the patients with diabetes in Pakistan: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Pooled it
- Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Effect of electroacupuncture for pain relief in diabetic distal symmetric polyneuropathy: a pilot randomized clinical trial.BMC complementary medicine and therapies · 2025Trial
- An Open-Label Comparative Study of the Impact of Two Types of Electrical Stimulation (Direct Current Neuromuscular Electrical Stimulation and Transcutaneous Electrical Stimulation) on Physical Therapy Treatment of Diabetic Peripheral Neuropathy.Journal of diabetes research · 2025Trial
- Improving Inclusion of Ethnically Diverse and Socioeconomically Disadvantaged Populations in Pain Research: A Comprehensive Review and Evidence-Based Recommendations.International journal of environmental research and public health · 2026Review
- Cross-cultural adaptation and validation of the Diabetic Foot Questionnaire (DiaFootQ) into Spanish Language.Atencion primaria · 2026Observational
- Diabetic peripheral neuropathy in type 2 diabetes: prevalence and associated factors in Midwest Brazil.Archives of endocrinology and metabolism · 2026Article
- Article
- A New Simple SCreening Tool for Painful Diabetic Neuropathy (ACT) in Ecuador.Journal of the peripheral nervous system : JPNS · 2026Observational
- Clinical characteristics of patients with diabetic peripheral neuropathy: a retrospective descriptive study.Frontiers in clinical diabetes and healthcare · 2026Article
- Influence of Genomic Ancestry and Other Traditional Risk Factors on the Prevalence of Diabetic Peripheral Neuropathy in Admixed Individuals With Type 1 Diabetes in Brazil: A Pioneer Multicenter Study.Journal of the peripheral nervous system : JPNS · 2025Article
- Genetics of diabetes and its complications: a comprehensive review.Diabetology & metabolic syndrome · 2025Review
- The global and regional burden of diabetic peripheral neuropathy.Nature reviews. Neurology · 2025Review
- Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy.Pharmaceutical biology · 2024Review
- Whether coagulation dysfunction influences the onset and progression of diabetic peripheral neuropathy: A multicenter study in middle-aged and aged patients with type 2 diabetes.CNS neuroscience & therapeutics · 2024Article
- Evaluating the Antihyperalgesic Potential of Sildenafil-Metformin Combination and Its Impact on Biochemical Markers in Alloxan-Induced Diabetic Neuropathy in Rats.Pharmaceuticals (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe objective of this systematic review and meta-analysis is to estimate the prevalence and incidence of diabetic peripheral neuropathy (DPN) in Latin America and the Caribbean (LAC). MATERIALS AND
methodsWe searched MEDLINE, SCOPUS, Web of Science, EMBASE and LILACS databases of published observational studies in LAC up to December 2020. Meta-analyses of proportions were performed using random-effects models using Stata Program 15.1. Heterogeneity was evaluated through sensitivity, subgroup, and meta-regression analyses. Evidence certainty was performed with the GRADE approach.
resultsTwenty-nine studies from eight countries were included. The estimated prevalence of DPN was 46.5% (95%CI: 38.0-55.0) with a significant heterogeneity (I2 = 98.2%; p<0.01). Only two studies reported incidence, and the pooled effect size was 13.7% (95%CI: 10.6-17.2). We found an increasing trend of cumulative DPN prevalence over time. The main sources of heterogeneity associated with higher prevalence were diagnosis criteria, higher A1c (%), and inadequate sample size. We judge the included evidence as very low certainty.
conclusionThe overall prevalence of DPN is high in LAC with significant heterogeneity between and within countries that could be explained by population type and methodological aspects. Significant gaps (e.g., under-representation of most countries, lack of incidence studies, and heterogenous case definition) were identified. Standardized and population-based studies of DPN in LAC are needed.
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