ArticlePloS one2021
Intra-abdominal hypertension and abdominal compartment syndrome in the critically ill liver cirrhotic patient-prevalence and clinical outcomes. A multicentric retrospective cohort study in intensive care.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05172531 (Efficacy and Safety Profile of Cisatracurium Besylate for Intra-abdominal Hypertensiona), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety Profile of Cisatracurium Besylate for Intra-abdominal Hypertensiona: Single Center, Randomized, Controlled Trial
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Microwave Radar Sensing for Non-Invasive Intra-Abdominal Pressure Monitoring: A Simulation-Based Analysis with Phantom Testing.Sensors (Basel, Switzerland) · 2026Article
- Inferior Vena Cava Syndrome.ACG case reports journal · 2026Article
- Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Contribution of tissue oximetry to the assessment of renal dysfunction in abdominal compartment syndrome: an experimental canine study.Frontiers in surgery · 2026Article
- Variation and accuracy of intra-abdominal pressure measurement in different body positions: a prospective study.World journal of emergency surgery : WJES · 2025Article
- Renal perfusion pressure: role and implications in critical illness.Annals of intensive care · 2025Review
- From past to present to future: Terlipressin and hepatorenal syndrome-acute kidney injury.Hepatology (Baltimore, Md.) · 2025Review
- Predicting intra-abdominal hypertension using anthropometric measurements and machine learning.Scientific reports · 2025Observational
- Intra-Abdominal Hypertension and Its Prognostic Impact on Mortality in Cirrhotic Patients with Ascites: The Role of Paracentesis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- An Introduction to Ventra: A Programmable Abdominal Phantom for Training, Educational, Research, and Development Purposes.Sensors (Basel, Switzerland) · 2024Article
- A clinical-radiomics nomogram for the prediction of the risk of upper gastrointestinal bleeding in patients with decompensated cirrhosis.Frontiers in medicine · 2024Article
- Abdominal compartment syndrome in critically ill patients.Acute and critical care · 2023Article
- Evaluation of the TraumaGuard Balloon-in-Balloon Catheter Design for Intra-Abdominal Pressure Monitoring: Insights from Pig and Human Cadaver Studies.Sensors (Basel, Switzerland) · 2023Article
- In Vitro Validation of a Novel Continuous Intra-Abdominal Pressure Measurement System (TraumaGuard).Journal of clinical medicine · 2023Article
- Article
- Abdominal perfusion pressure in critically ill cirrhotic patients: a prospective observational study.Scientific reports · 2023Observational
- The intracranial compartmental syndrome: a proposed model for acute brain injury monitoring and management.Critical care (London, England) · 2023Review
- Article
- Cross-sectional study exploring the characteristics of hospitalized patients admitted for acute pancreatitis who develop abdominal compartment syndrome in US hospitals.Proceedings (Baylor University. Medical Center)Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver cirrhosis and ascites are risk factors for intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS); however, data is scarce. We aimed to determine the prevalence of IAH/ACS in a population of critically ill cirrhotic patients with acute medical illness in intensive care and to assess for risk factors and clinical outcomes.
methodsThis was a multicentric retrospective cohort study including two general ICUs and pooled data from a multicentric study between January 2009 and October 2019.
resultsA total of 9,345 patients were screened, and 95 were included in the analysis. Mean age was 56.7±1.3 years, and 79% were male. Liver cirrhosis etiology included alcohol in 45.3% and alcohol plus hepatitis C virus in 9.5%. Precipitating events included infection in 26% and bleeding in 21% of cases. Mean severity score MELD and SAPS II were 26.2±9.9 and 48.5±15.3, respectively, at ICU admission. The prevalence of IAH and ACS was respectively 82.1% and 23.2% with a mean value of maximum IAP of 16.0±5.7 mmHg and IAH grades: absent 17.9%, I 26.3%, II 33.7%, III 17.9%, and IV 4.2%. Independent risk factors for IAH were alcoholic cirrhosis (p = 0.01), West-Haven score (p = 0.01), and PaO2/FiO2 ratio (p = 0.02); as well as infection (p = 0.048) for ACS. Overall, 28-day mortality was 52.6% associated with higher IAP and ACS, and independent risk factors were MELD (p = 0.001), white blood cell count (p = 0.03), PaO2/FiO2 ratio (p = 0.03), and lactate concentration (p = 0.04) at ICU admission.
conclusionsThis study demonstrates a very high prevalence of IAH/ACS in the critically ill cirrhotic patient in intensive care. Increased IAP and ACS were associated with severity of disease and adverse outcomes and independent risk factors for IAH were alcoholic cirrhosis, hepatic encephalopathy and PO2/FiO2 ratio, as well as infection for ACS. Early diagnosis, prevention, and treatment of IAH/ACS might improve outcome in critically ill cirrhotic patients.
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