Observational studyPloS one2021
Determining a target SpO2 to maintain PaO2 within a physiological range.
Observational study in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Oxygen Saturation Thresholds for Opioid-induced Respiratory Depression: A Systematic Review.The western journal of emergency medicine · 2026Pooled it
- Effect of salbutamol during one-lung ventilation in patients with chronic obstructive pulmonary disease: a randomized controlled trial.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Trial
- The Effect of Foot Reflexology Massage on Delirium and Physiological Indicators in Children Admitted to Pediatric Intensive Care Unit: A Randomized Clinical Trial.TheScientificWorldJournal · 2026Trial
- Novel Triple-Cuff versus Conventional Double-Cuff Double-Lumen Endobronchial Tube in Patients with Risk Factors for Tube Misdirection.Yonsei medical journal · 2025Trial
- Driving pressure guided ventilation versus conventional lung protective strategy in morbid obese patients undergoing laparoscopic bariatric surgery: a prospective randomized controlled study.BMC anesthesiology · 2025Trial
- Remimazolam Preserves Oxygen Reserve and Improves Sedation Safety Compared to Propofol in Endoscopic Retrograde Cholangiopancreatography.United European gastroenterology journal · 2025Trial
- Effect of remimazolam on oxygen reserve compared with propofol during upper gastrointestinal endoscopy: Randomized controlled study.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Trial
- Peripheral Oxygen Saturation Targets and Hyperoxemia in Critical Care: Influence of pH, FAntioxidants (Basel, Switzerland) · 2026Article
- The Utility of Umbilical Cord Pulse Oximetry-A Translational Study with Four Minutes of Deferred Cord Clamping Using an Asphyxiated Preterm Ovine Model.Children (Basel, Switzerland) · 2025Article
- Comparing supervised machine learning algorithms for the prediction of partial arterial pressure of oxygen during craniotomy.BMC medical informatics and decision making · 2025Article
- Tackling inter-subject variability in smartwatch data using factorization models.Scientific reports · 2025Article
- Variable cerebral blood flow responsiveness to acute hypoxic hypoxia.Frontiers in physiology · 2025Article
- The efficacy and safety of combined therapy with endobronchial tamponade and bronchial artery embolization for massive hemoptysis.BMC pulmonary medicine · 2024Article
- Gastric Insufflation with High Flow Nasal Oxygen Therapy in Adult Patients Admitted to Intensive Care Unit: An Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Oxygen titration with Oxygen Reserve Index in minimally invasive repair of pectus excavatum, a randomized controlled trial.Northern clinics of Istanbul · 2024Article
- Hyperoxemia post thoracic surgery - Does it matter?Heliyon · 2023Article
- The Effects of Foot Reflexology on Vital Signs: A Meta-Analysis of Randomized Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Using a Quality Improvement Initiative to Decrease Oxygen Toxicity among Mechanically Ventilated Children.Pediatric quality & safetyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the context of an ongoing debate on the potential risks of hypoxemia and hyperoxemia, it seems prudent to maintain the partial arterial oxygen pressure (PaO2) in a physiological range during administration of supplemental oxygen. The PaO2 and peripheral oxygen saturation (SpO2) are closely related and both are used to monitor oxygenation status. However, SpO2 values cannot be used as an exact substitute for PaO2. The aim of this study in acutely ill and stable patients was to determine at which SpO2 level PaO2 is more or less certain to be in the physiological range.
methodsThis is an observational study prospectively collecting data pairs of PaO2 and SpO2 values in patients admitted to the emergency room or intensive care unit (Prospective Inpatient Acutely ill cohort; PIA cohort). A second cohort of retrospective data of patients who underwent pulmonary function testing was also included (Retrospective Outpatient Pulmonary cohort; ROP cohort). Arterial hypoxemia was defined as PaO2 < 60 mmHg and hyperoxemia as PaO2 > 125 mmHg. The SpO2 cut-off values with the lowest risk of hypoxemia and hyperoxemia were determined as the 95th percentile of the observed SpO2 values corresponding with the observed hypoxemic and hyperoxemic PaO2 values.
results220 data pairs were collected in the PIA cohort. 95% of hypoxemic PaO2 measurements occurred in patients with an SpO2 below 94%, and 95% of hyperoxemic PaO2 measurements occurred in patients with an SpO2 above 96%. Additionally in the 1379 data pairs of the ROP cohort, 95% of hypoxemic PaO2 measurements occurred in patients with an SpO2 below 93%.
conclusionThe SpO2 level marking an increased risk of arterial hypoxemia is not substantially different in acutely ill versus stable patients. In acutely ill patients receiving supplemental oxygen an SpO2 target of 95% maximizes the likelihood of maintaining PaO2 in the physiological range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.