ReviewCirculation research2021
Reverse Remodeling With Left Ventricular Assist Devices.
Review in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Cardiac unloading models for myocardial reverse remodeling.Basic research in cardiology · 2026Review
- Managing Cardiogenic Shock in the Era of Multimodal Mechanical Support: Bridging to Transplant or Recovery.Current heart failure reports · 2026Review
- Prognostic significance of atrial fibrillation resolution after left ventricular assist device implantation.JHLT open · 2026Article
- Hemodynamics in heart: the critical role of hemodynamics in myocardial tissue development and regenerative remodeling.International journal of cardiology. Heart & vasculature · 2026Review
- Recovery From Heart Failure: Microvascular Mechanisms.Circulation · 2026Article
- Perioperative Care and Clinical Outcomes of Patients with Left Ventricular Assist Devices Undergoing Noncardiac Surgery in Korea: A Retrospective Study.Journal of clinical medicine · 2026Article
- Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation.Journal of cardiovascular development and disease · 2026Review
- Novel markers of myocardial recovery in patients with left ventricular assist device: A cardiopulmonary exercise test and hemodynamic analysis.JHLT open · 2026Article
- Nanoparticle-Based Therapeutic Strategies for Pathological Cardiac Hypertrophy: Preclinical Advances, Translational Challenges, and Future Perspectives.International journal of nanomedicine · 2026Review
- Effects of Isovolumic Loading Elicited Either by 3-Branch or by 4-Branch Spring Expander on the Degree of Cardiac Atrophy of the Failing Heart in Rats After Heterotopic Heart Transplantation: No Evidence for Sex-Linked Differences.Physiological research · 2025Article
- Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors.Epigenetics · 2025Article
- Predictors of Left Ventricular Reverse Remodeling in Heart Failure with Reduced Ejection Fraction.Current heart failure reports · 2025Review
- Alterations in implantable cardioverter defibrillator lead parameters following left ventricular assist device implantation.JHLT open · 2025Article
- Echocardiographic assessment of a novel blood-guiding accessory for left ventricular assist devices in swine.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Obesity and heart failure: exploring the cardiometabolic axis.Cardiovascular research · 2025Review
- Molecular Mechanisms of Cardiac Adaptation After Device Deployment.Journal of cardiovascular development and disease · 2025Review
- Intraventricular spring expander attenuates cardiac atrophy of the failing heart after unloading caused by heterotopic heart transplantation: no sex-linked differences.Physiological research · 2025Article
- Left Atrial Reverse Remodeling in Patients Supported With Durable Left Ventricular Assist Devices and Clinical Implications.Circulation. Heart failure · 2025Article
- Myocardial functional recovery following durable ventricular assist device in children.JHLT open · 2025Article
- A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.Circulation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This review provides a comprehensive overview of the past 25+ years of research into the development of left ventricular assist device (LVAD) to improve clinical outcomes in patients with severe end-stage heart failure and basic insights gained into the biology of heart failure gleaned from studies of hearts and myocardium of patients undergoing LVAD support. Clinical aspects of contemporary LVAD therapy, including evolving device technology, overall mortality, and complications, are reviewed. We explain the hemodynamic effects of LVAD support and how these lead to ventricular unloading. This includes a detailed review of the structural, cellular, and molecular aspects of LVAD-associated reverse remodeling. Synergisms between LVAD support and medical therapies for heart failure related to reverse remodeling, remission, and recovery are discussed within the context of both clinical outcomes and fundamental effects on myocardial biology. The incidence, clinical implications and factors most likely to be associated with improved ventricular function and remission of the heart failure are reviewed. Finally, we discuss recognized impediments to achieving myocardial recovery in the vast majority of LVAD-supported hearts and their implications for future research aimed at improving the overall rates of recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.