ArticleEuropean journal of neurology2021
Impaired fixation suppression of horizontal vestibular nystagmus during smooth pursuit: pathophysiology and clinical implications.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Eye movements and ocular biomarkers in mild traumatic brain injury: from oculomotor pathophysiology to diagnosis and prognosis.Journal of neurology · 2026Review
- Optimising electrical vestibular stimulation (EVS) for assessing vestibular function.Clinical neurophysiology practice · 2025Article
- Clinical Differences between Radiographic and Physical Horizontal Gaze Deviation: Utility of Using the Two in Patients with Ischemic Stroke.The Neurohospitalist · 2024Article
- Visual Fixation of Skull-Vibration-Induced Nystagmus in Patients with Peripheral Vestibulopathy.Audiology research · 2024Article
- Open Iris - An Open Source Framework for Video-Based Eye-Tracking Research and Development.bioRxiv : the preprint server for biology · 2024Article
- Nystagmus only with fixation in the light: a rare central sign due to cerebellar malfunction.Journal of neurology · 2022Article
- Artificial intelligence for early stroke diagnosis in acute vestibular syndrome.Frontiers in neurology · 2022Article
- Bruns' nystagmus revisited: A sign of stroke in patients with the acute vestibular syndrome.European journal of neurology · 2021Article
- Impaired fixation suppression of horizontal vestibular nystagmus during smooth pursuit: pathophysiology and clinical implications.European journal of neurology · 2021Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeA peripheral spontaneous nystagmus (SN) is typically enhanced or revealed by removing fixation. Conversely, failure of fixation suppression of SN is usually a sign of a central disorder. Based on Luebke and Robinson (Vision Res 1988, vol. 28 (8), pp. 941-946), who suggested that the normal fixation mechanism is disengaged during pursuit, it is hypothesized that vertical tracking in the light would bring out or enhance a horizontal SN.
methodsEighteen patients with acute vestibular neuritis were studied. Eye movements were recorded using video-oculography at straight-ahead gaze with and without visual fixation, and during smooth pursuit. The slow-phase velocity and the fixation suppression indices of nystagmus (relative to SN in darkness) were compared in each condition.
resultsDuring vertical tracking, the slow-phase velocity of horizontal SN with eyes near straight-ahead gaze was significantly higher (median 2.7°/s) than under static visual fixation (median 1.2°/s). Likewise, the fixation index was significantly higher (worse suppression) during pursuit (median 48%) than during fixation (median 26%). A release of SN was also suggested during horizontal pursuit, if one assumes superposition of SN on a normal and symmetrical pursuit capability.
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