Evidence map›Paper›PMID 33983547›Full record

ArticleMolecular neurobiology2021

Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics.

Mingxuan Ding, Kenta Teruya, Weiguanliu Zhang, Hae Weon Lee, Jue Yuan, Ayumi Oguma, Aaron Foutz, Manuel V Camacho, Marcus Mitchell, Justin J Greenlee and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Tracking Prions by RT-QuIC: An Update.Sub-cellular biochemistry · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Mingxuan DingDepartment of Neurology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Kenta TeruyaDepartment of Neurochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Weiguanliu ZhangDepartment of Neurology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Hae Weon LeeDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Jue YuanDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Ayumi OgumaDepartment of Neurochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Aaron FoutzDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Manuel V CamachoDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Marcus MitchellDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Justin J GreenleeVirus and Prion Research Unit, Agricultural Research Service, National Animal Disease Center, USDA, 1920 Dayton Avenue, Ames, IA, 50010, USA.
Qingzhong KongDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Katsumi Doh-UraDepartment of Neurochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. doh-ura@med.tohoku.ac.jp.
Li CuiDepartment of Neurology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China. chuili1967@126.com.
Wen-Quan ZouDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. wxz6@case.edu.ORCID http://orcid.org/0000-0001-8062-0370
University School · USJilin University · CNTohoku University · JPAgricultural Research Service · USCase Western Reserve University · US

Funding

Role of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9M
Foundation for Promotion of Material Science and Technology of Japan (JP) 19K22479Innovative Research Group Project of the National Natural Science Foundation of China 81671186Japan Agency for Medical Research and Development 16ek0109012h0003NINDS NIH HHS R01 NS109532
6 · The paper itself

Abstract

Previous studies have revealed that the infectious scrapie isoform of prion protein (PrP

Indexed as

AnimalsBiomarkersBrainMiceMice, TransgenicPrion DiseasesPrPSc ProteinsSkinBiomarkersPrPSc ProteinsCellulose ethersPrion diseasesPrionsReal-time quaking-induced conversion (RT-QuIC)Serial protein misfolding cyclic amplification (sPMCA)TC-5RW

Identifiers

PMID33983547
PMCPMC8487418
OpenAlexW3162061868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.