Evidence map›Paper›PMID 33983502›Full record

ArticleArchives of virology2021

Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.

Anastasiya S Sokolova, Olga I Yarovaya, Darya V Baranova, Anastasia V Galochkina, Anna A Shtro, Marina V Kireeva, Sophia S Borisevich, Yuriy V Gatilov, Vladimir V Zarubaev, Nariman F Salakhutdinov

Abstract read
In one paragraph

Article in Archives of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anastasiya S SokolovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090. asokolova@nioch.nsc.ru.ORCID http://orcid.org/0000-0001-5227-9996
Olga I YarovayaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.
Darya V BaranovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.
Anastasia V GalochkinaPasteur Institute of Epidemiology and Microbiology, 14 Mira str., St. Petersburg, Russia, 197101.
Anna A ShtroDepartment of Chemotherapy, Influenza Research Institute, 15/17 Prof. Popova St., St. Petersburg, Russia, 197376.
Marina V KireevaSaint Petersburg State University, 7/9 Universitetskaya nab., St. Petersburg, Russia, 199034.
Sophia S BorisevichLaboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, Ufa, Russia, 450078.
Yuriy V GatilovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.
Vladimir V ZarubaevPasteur Institute of Epidemiology and Microbiology, 14 Mira str., St. Petersburg, Russia, 197101.
Nariman F SalakhutdinovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.

Funding

Russian Scientific Foundation 19-73-00125
6 · The paper itself

Abstract

A series of compounds containing a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment were evaluated for their antiviral activity against influenza A virus strain A/Puerto Rico/8/34 (H1N1) in vitro. The most potent antiviral compound proved to be a quaternary ammonium salt based on (-)-borneol, 10a. In in vitro experiments, compound 10a inhibited influenza A viruses (H1, H1pdm09, and H3 subtypes), with an IC

Indexed as

AlkanesAmmonium CompoundsAnimalsAntiviral AgentsCamphanesCell LineDogsHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H1N1 SubtypeMadin Darby Canine Kidney CellsOrthomyxoviridae InfectionsQuaternary Ammonium CompoundsSaltsAlkanesAmmonium CompoundsAntiviral AgentsCamphanesHemagglutinin Glycoproteins, Influenza VirusisoborneolQuaternary Ammonium Compoundsquaternary bisammonium saltSalts

Identifiers

PMID33983502
PMCPMC8116641

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.