SynthesisEndocrine2021
Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis.
Synthesis in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review.BMC pregnancy and childbirth · 2026Pooled it
- Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones.Thyroid : official journal of the American Thyroid Association · 2025Pooled it
- Autoimmune diseases and adverse pregnancy outcomes: an umbrella review.BMC medicine · 2024Pooled it
- Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Thyroid antibody positivity in pregnancy is associated with altered reproductive hormone concentrations and placental growth in Lewis rats.The Journal of physiology · 2026Article
- First-trimester free thyroxine as an independent predictor of gestational diabetes mellitus: a retrospective cohort study.Advances in laboratory medicine · 2026Article
- The Impact of Maternal Diabetes and Hypothyroidism on Signaling Pathway Activation and Gene Expression in Fetal Mesenchymal Stem Cells.Biomedicines · 2026Article
- Low FT4 levels in early pregnancy are associated with higher insulin therapy need in women with gestational diabetes mellitus.European thyroid journal · 2026Article
- Thyroid Hormones in Early Pregnancy and Birth Weight: A Retrospective Study.Biomedicines · 2025Article
- Higher prevalence of gestational diabetes in euthyroid women with thyroid autoimmunity who were expecting a female fetus.European thyroid journal · 2025Article
- Gestational diabetes: a contributor to long-term thyroid dysfunction and disease.Frontiers in endocrinology · 2025Article
- Application of machine learning algorithm incorporating dietary intake in prediction of gestational diabetes mellitus.Endocrine connections · 2024Article
- Overt hypothyroidism in pregnancy and language development in offspring: is there an association?Journal of endocrinological investigation · 2024Article
- Article
- Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024Article
- Association Between Maternal Thyroid Function in Early Pregnancy and Gestational Diabetes: A Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2024Article
- The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors.Annals of medicine · 2023Article
- Impact of thyroid hormone treatment on maternal pregnancy outcomes in women with subclinical hypothyroidism without TPOAb: a retrospective cross-sectional study.Thyroid research · 2023Article
- Adherence to the Mediterranean diet and risk of gestational diabetes: a prospective cohort study.BMC pregnancy and childbirth · 2023Article
- An Evaluation of the Second Trimester Thyroid Function Test in Gestational Diabetes Mellitus: A Case-Control Study.Cureus · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe current meta-analysis aimed to evaluate the association of thyroid dysfunction and autoimmunity with gestational diabetes mellitus (GDM).
methodsA comprehensive search from PubMed, Embase, MEDLINE, and Cochrane databases until November 2020 was conducted. Fixed-effect model was used to combine the results when I
resultsA total of 44 studies were included in the meta-analysis. Low FT4 levels were closely related with GDM in the first and second trimesters of gestation. Hypothyroxinemia (OR: 1.45; 95% CI: 1.25, 1.68; P < 0.00001), overt (OR: 1.80; 95% CI: 1.73, 1.86; P < 0.00001), and subclinical (OR: 1.54; 95% CI: 1.03, 2.30; P = 0.03) hypothyroidism, overt hyperthyroidism (OR: 1.49; 95% CI: 1.09, 2.04; P = 0.01), and positive thyroid antibodies (OR: 1.49; 95% CI: 1.07, 2.07; P < 0.00001) were observed significantly associated with the risk of GDM. Pregnant women with subclinical hyperthyroidism were less likely to develop GDM (OR: 0.62; 95% CI: 0.39, 0.97; P = 0.04).
conclusionsThyroid dysfunction and positive thyroid antibodies were associated with the risk of GDM. Our findings suggest that pregnant women with these thyroid diseases may be offered screening for GDM comprehensively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.