ArticleAMB Express2021
Effects of organic acid, Enterococcus faecalis strain EC-12 and sugar cane extract in feed against enterotoxigenic Escherichia coli-induced diarrhea in pigs.
Article in AMB Express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Differences in Intestinal Flora and Its Related Metabolite Between Healthy and Diarrheal Piglets: Strategies for Innovative Bacterial Diarrhea Prevention.Animals : an open access journal from MDPI · 2026Article
- Review
- Tracing enterococci persistence along a pork production chain from feed to food in China.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Drinking Water Supplemented with Acidifiers Improves the Growth Performance of Weaned Pigs and Potentially Regulates Antioxidant Capacity, Immunity, and Gastrointestinal Microbiota Diversity.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhea can lead to mortality and delayed growth in pigs and is a major economic loss in the pig industry. In this study, we evaluated non-antimicrobial materials that can prevent diarrhea to infection by enterotoxigenic Escherichia coli (ETEC) in weaned pigs and investigated biological changes. We confirmed the efficacy of fumaric acid, lactic acid, Enterococcus faecalis strain EC-12 (EC12) and sugar cane extract (SCE) in inhibiting diarrhea and investigated the biological changes by analyzing gut microbiota and plasma metabolites. Administration of EC12 (0.1%, w/w) and SCE (1.0%, w/w) groups had reduced score of diarrhea. Furthermore, the combination of EC12 and SCE was effective at reducing the fecal score of diarrhea even at low concentrations. Administration of either EC12 or SCE greatly reduced the relative abundance of Enterobacteriaceae in pigs. EC12 and SCE were most effective in suppressing ETEC-induced diarrhea in weaned pigs. Furthermore, we were able to identify biological changes in pigs when EC12 and SCE were administered to pigs. These feeds may have prevented infection by ETEC in weaned pigs and may improve pig productivity and reduce the use of antimicrobial agents.
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What OpenQuestion holds
Registered trials
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