Evidence map›Paper›PMID 33983131›Full record

ArticleJMIR research protocols2021

Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial.

Sheri J Hartman, Lindsay W Dillon, Andrea Z LaCroix, Loki Natarajan, Dorothy D Sears, Neville Owen, David W Dunstan, James F Sallis, Simon Schenk, Matthew Allison and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03473145 (Sedentary Behavior Interrupted), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03473145 nacompletednot on this map

Sedentary Behavior Interrupted: A Randomized Trial of 3-month Effects on Biomarkers of Healthy Aging and Physical Functioning in the Real World (Project 2)

TypeinterventionalSponsorUniversity of California, San DiegoRan2018 to 2024Enrolled407ConditionsSedentary LifestyleArmsHealth Coaching, activPAL inclinometer, Tools to Prompt Standing or Prompt Sit-to-Stand Transitions.
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors.The international journal of behavioral nutrition and physical activity · 2024
    Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Sheri J HartmanHebert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-3719-0624
Lindsay W DillonHebert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-1151-7350
Andrea Z LaCroixHebert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-9532-976X
Loki NatarajanHebert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0001-5719-828X
Dorothy D SearsMoores Cancer Center, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-9260-3540
Neville OwenBaker Heart and Diabetes Institute, Melbourne, Australia.ORCID https://orcid.org/0000-0003-2784-4820
David W DunstanBaker Heart and Diabetes Institute, Melbourne, Australia.ORCID https://orcid.org/0000-0003-2629-9568
James F SallisHebert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0003-2555-9452
Simon SchenkDepartment of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-8224-3203
Matthew AllisonDepartment of Family Medicine, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0003-0777-8272
Michelle TakemotoServiceNow, Santa Clara, CA, United States.ORCID https://orcid.org/0000-0002-6061-3226
Alexandra M HerweckHebert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-6552-0993
Bao NguyenSchool of Medicine, University of California, San Diego, La Jolla, CA, United States.ORCID https://orcid.org/0000-0002-6945-3353
Dori E RosenbergKaiser Permanente Washington Health Research Institute, Seattle, WA, United States.ORCID https://orcid.org/0000-0003-1017-8833
University of California San Diego · USBaker Heart and Diabetes Institute · AUKaiser Permanente Washington Health Research Institute · USServiceNow (United States) · US

Funding

Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortalityP01AG052352 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACROIX, ANDREA Z. · 2017 to 2022
$9.0M
NIA NIH HHS P01 AG052352
6 · The paper itself

Abstract

backgroundMany older adults spend the majority of their waking hours sitting, which increases their risk of chronic diseases. Given the challenges that many older adults face when engaging in moderate-to-vigorous physical activity, understanding the health benefits of decreasing sitting time and increasing the number of sit-to-stand transitions is needed to address this growing public health concern.

objectiveThe aim of this 3-arm randomized controlled trial is to investigate how changes in sitting time and brief sit-to-stand transitions impact biomarkers of healthy aging and physical, emotional, and cognitive functioning compared with a healthy attention control arm.

methodsSedentary and postmenopausal women (N=405) will be recruited and randomly assigned to 1 of the 3 study conditions for 3 months: healthy living attention control (Healthy Living), reduce sitting time (Reduce Sitting), and increase sit-to-stand transitions (Increase Transitions). Assessments conducted at baseline and 3 months included fasting blood draw, blood pressure, anthropometric measurements, physical functioning, cognitive testing, and 7 days of a thigh-worn accelerometer (activPAL) and a hip-worn accelerometer (ActiGraph). Blood-based biomarkers of healthy aging included those associated with glycemic control (glycated hemoglobin, fasting plasma insulin and glucose, and homeostatic model assessment of insulin resistance).

resultsRecruitment began in May 2018. The intervention is ongoing, with data collection expected to continue through the end of 2022.

conclusionsThe Rise for Health study is designed to test whether 2 different approaches to interrupting sitting time can improve healthy aging in postmenopausal women. Results from this study may inform the development of sedentary behavior guidelines and interventions to reduce sitting time in older adults.

trial registrationClinicalTrials.gov NCT03473145; https://clinicaltrials.gov/ct2/show/NCT03473145. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/28684.

Indexed as

biomarkerscardiometabolic healthcognitive functionolder adultsphysical functionsedentary behavior

Identifiers

PMID33983131
PMCPMC8160808
OpenAlexW3149848734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.