ArticleEuropean journal of pain (London, England)2021
Dissecting pain processing in adolescents with Non-Suicidal Self Injury: Could suicide risk lurk among the electrodes?
Article in European journal of pain (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- How the Brain Interprets Pain in Autistic People: Does Sex Matter?European journal of pain (London, England) · 2026Article
- Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women.Brain and behavior · 2026Article
- Quantitative Sensory Testing Identifies Altered Thermal and Pain Processing in Trigeminal Neuralgia.European journal of neurology · 2026Article
- Factors influencing suicidal ideation in Chinese adolescents with first-episode depressive disorder: a cross-sectional study.BMC psychology · 2026Article
- Study of pain perception under negative emotions and its large-scale brain network dynamics in adolescents with non-suicidal self-injury.Frontiers in psychiatry · 2025Article
- A Systematic Review and Meta-Analysis of Conditioned Pain Modulation in Children and Young People with Chronic Pain.Children (Basel, Switzerland) · 2024Review
- [Advances in the electrophysiological research on neurocognitive function in adolescents with non-suicidal self-injury].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Modeling and controlling the body in maladaptive ways: an active inference perspective on non-suicidal self-injury behaviors.Neuroscience of consciousness · 2023Article
- Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study.Frontiers in neuroscience · 2022Article
- Dissecting pain processing in adolescents with Non-Suicidal Self Injury: Could suicide risk lurk among the electrodes?European journal of pain (London, England) · 2021Article
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Authors and funding
12 authors at 1 institution in 1 country.
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Abstract
backgroundAlthough non-suicidal self-injury (NSSI) disorder is highly prevalent in adolescents, its relationship with pain system function and suicidality is still controversial. The present study was designed to assess the function of the nociceptive afferent pathways and the endogenous pain modulation in adolescent patients with NSSI and to longitudinally register any suicide attempt, describe its frequency and find a possible association between suicide, neurophysiological measures and psychological measures.
methodsWe enrolled 30 adolescents suffering from NSSI and 20 age- and gender-matched healthy controls. Patients underwent a comprehensive psychological evaluation. Each participant underwent thermal pain thresholds of the quantitative sensory testing, laser-evoked potential recording to study the ascending nociceptive pathway and the conditioned pain modulation testing to test the endogenous pain modulation.
resultsWe found that patients with NSSI had a reduced amplitude of the N2 component of laser-evoked potentials and an abnormal conditioned pain modulation. The amplitude of the N2 was associated with suicidal risk.
conclusionsThe deficit of the endogenous pain modulation likely depends on a saturation due to continuous pain solicitation. The strong association of a reduced amplitude of the N2 component with suicide suggests that it may serve as a possible biomarker in self-harming adolescents. SIGNIFICANCE: The present study identifies the N2 component of laser-evoked potentials as a possible neurophysiological biomarker of suicidal risk in patients with non-suicidal self-injury, therefore, raising the possibility for a non-invasive test to identify subjects at higher risk of suicide among self-harming patients.
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