Evidence map›Paper›PMID 33982674›Full record

ArticleAging2021

Sevoflurane protects against ischemia-reperfusion injury in mice after total knee arthroplasty via facilitating RASD1-mediated protein kinase A pathway activation.

Tao Li, Yangdong Han, Baofu Guo, Peng Chen, Yingchun Wan, Baoguo Ye

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tao LiDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130031, P.R. China.
Yangdong HanDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130031, P.R. China.
Baofu GuoDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130031, P.R. China.
Peng ChenDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130031, P.R. China.
Yingchun WanDepartment of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun 130031, P.R. China.
Baoguo YeDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130031, P.R. China.
Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to explore effects of Sevoflurane on ischemia-reperfusion (I/R) injury after total knee arthroplasty (TKA). To explore potential molecular mechanism, Ras related dexamethasone induced 1 (RASD1), a Protein kinase A (PKA) activator, frequently associated with various models of I/R injury, was also investigated.

Indexed as

AnimalsApoptosisArthroplasty, Replacement, KneeCell ProliferationCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinDisease Models, AnimalMiceProtective Agentsras ProteinsReperfusion InjurySevofluraneCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinProtective AgentsRasd1 protein, mouseras ProteinsSevofluranecAMP signaling pathwayischemia-reperfusion injuryRASD1Sevofluranetotal knee arthroplasty

Identifiers

PMID33982674
PMCPMC8148473
OpenAlexW3163080487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.