Evidence map›Paper›PMID 33982351›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p/TGF-β2 axis.

Sai Zhu, Xin Chen, Jia-Nan Wang, Jin-Jin Xu, Ao Wang, Juan-Juan Li, Sha Wu, Yuan-Yuan Wu, Xiao-Feng Li, Cheng Huang and 1 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Role of Circular RNAs in Liver Diseases.International journal of medical sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. m6A demethylase Fto inhibited macrophage activation and glycolysis in diabetic nephropathy via m6A/Npas2/Hif-1α axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Review
  9. Circular RNAs in Liver Diseases.Advances in experimental medicine and biology · 2025
    Review
  10. Acta pharmaceutica Sinica. B · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. CircRNAs: versatile players and new targets in organ fibrosis.Cell communication and signaling : CCS · 2023
    Review
  19. Role of noncoding RNAs in liver fibrosis.World journal of gastroenterology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sai ZhuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Xin ChenInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Jia-Nan WangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Jin-Jin XuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Ao WangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Juan-Juan LiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Sha WuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Yuan-Yuan WuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Xiao-Feng LiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Cheng HuangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Jun LiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abundant regulatory genes and complex circuits involving non-coding RNAs (ncRNAs) monitor the formation and development of hepatic fibrosis (HF). Circular RNAs (circRNAs) are a class of RNAs generated from protein coding genes by back-splicing, playing crucial roles in various pathological processes, including HF. However, little is known about mechanisms of action of circRNAs, let alone in HF. In this study, we found circUbe2k enhanced in CCl

Indexed as

Gene Expression RegulationAnimalsCarbon TetrachlorideCell ProliferationLiver CirrhosisMaleMiceMice, Inbred C57BLMicroRNAsRNA, CircularSignal TransductionTransforming Growth Factor beta2Ubiquitin-Conjugating EnzymesCarbon TetrachlorideMicroRNAsMIRN149 microRNA, mouseRNA, CircularTgfb2 protein, mouseTransforming Growth Factor beta2Ube2k protein, mouseUbiquitin-Conjugating EnzymescircUbe2kcircular RNAhepatic fibrosismiR-149-5pTGF-β2

Identifiers

PMID33982351
PMCPMC12315939
OpenAlexW3161409907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.