Trial reportEpilepsia2021
Supporting treatment adherence regimens in children with epilepsy: A randomized clinical trial.
Trial report in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Digital psychological interventions in youth with neurological disorders: a systematic review.Journal of pediatric psychology · 2026Pooled it
- Systematic review and meta-analysis of interventions to promote medication adherence among children, adolescents, and young adults with medical conditions.Journal of pediatric psychology · 2025Pooled it
- A simulation training of family management for parents of children with epilepsy: a randomized clinical trial.Italian journal of pediatrics · 2024Trial
- A randomized clinical trial to support adherence regimens in children with epilepsy: Examining potential mechanisms of change.Epilepsy & behavior : E&B · 2023Trial
- Key predictors of the need for a family-focused pediatric epilepsy adherence intervention.Epilepsia · 2022Trial
- Methods for analyzing longitudinal data from randomized pretest-posttest-follow-up trials in behavioral research: a practical guide to latent change models.Journal of behavioral medicine · 2026Article
- Health disparities in neurology.Nature reviews. Neurology · 2025Review
- Barriers to Medication Adherence in People Living With Epilepsy.Neurology. Clinical practice · 2025Article
- The eACT study design and methods: A sequential, multiple assignment, randomized trial of A novel adherence intervention for youth with epilepsy.Contemporary clinical trials · 2024Article
- Adjunctive interventions: change methods directed at recipients that support uptake and use of health innovations.Implementation science : IS · 2024Article
- Interventions to Improve Medication Adherence in Children With Epilepsy: A Systematic Review.Cureus · 2024Review
- Medication compliance of children with epilepsy: a cross-sectional survey.Italian journal of pediatrics · 2023Article
- Demystifying a family-based epilepsy adherence problem-solving intervention: Exploring adherence barriers and solutions.Clinical practice in pediatric psychology · 2023Article
- Barriers to medication adherence among adolescents and young adults with cancer.Pediatric blood & cancer · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study was undertaken to examine the efficacy of a family-tailored education and problem-solving behavioral intervention, Supporting Treatment Adherence Regimens (STAR), in young children (2-12 years old) with new onset epilepsy compared to an attention control (i.e., education only [EO]) intervention. Participants randomized to the STAR intervention were hypothesized to demonstrate significantly improved adherence at postintervention and 3-, 6-, and 12-month follow-up visits compared to the EO intervention. Seizure and health-related quality of life (HRQOL) outcomes were also examined.
methodsTwo hundred children with new onset epilepsy and their caregivers were recruited during routine epilepsy clinic visits. Baseline questionnaires were completed, and electronic adherence monitors were provided. Participants with adherence less than 95% during the run-in period were randomized to either STAR or EO intervention. Active intervention was provided to both groups for 4 months. Questionnaires were completed at conclusion of the active intervention phase and three follow-up time points (3, 6, and 12 months). Group differences in adherence, seizure outcomes, and HRQOL were examined using regression-based analyses of covariance and longitudinal mixed effect linear or logistical models.
resultsAdherence at 12-month follow-up was significantly different between the STAR (mean = 82.34, SD = 21.29) and EO intervention groups (mean = 61.77, SD = 28.29), with the STAR group demonstrating 20.6% greater adherence (b = 19.11, p = .04, 95% confidence interval = 1.00-37.22, d = .83). No significant differences were found between groups in seizure and HRQOL outcomes. SIGNIFICANCE: A family-based behavioral adherence intervention demonstrated sustained adherence improvements 1 year following epilepsy diagnosis compared to an epilepsy-specific education intervention. STAR is an efficacious adherence intervention that can easily be implemented into routine epilepsy care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.