Evidence map›Paper›PMID 33982215›Full record

ArticleHead and neck pathology2021

Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases.

Justin A Bishop, Dipti P Sajed, Ilan Weinreb, Brendan C Dickson, Elizabeth A Bilodeau, Abbas Agaimy, Alessandro Franchi, Syed Ali Khurram, Philip Da Forno, Juliana Robledo and 21 more

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Article in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Salivary gland microsecretory adenocarcinoma: a case series study and literature review.Virchows Archiv : an international journal of pathology · 2026
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  12. Article
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  19. Microsecretory adenocarcinoma of the external ear canal.Journal of cutaneous pathology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Justin A BishopDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX, USA. justin.bishop@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-9743-4360
Dipti P SajedDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Ilan WeinrebDepartment of Pathology, University Health Network, Toronto, ON, Canada.
Brendan C DicksonDepartment of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.
Elizabeth A BilodeauDepartment of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA.
Abbas AgaimyInstitute of Pathology, University Hospital of Erlangen, Erlangen, Germany.
Alessandro FranchiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Syed Ali KhurramUnit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, 19 Claremont Crescent, Sheffield, S10 2TA, UK.
Philip Da FornoDepartment of Cellular Pathology, University Hospitals of Leicester NHS Trust, Leicester, UK.
Juliana RobledoDepartment of Pathology and Laboratory Medicine, Long School of Medicine, UT Health, San Antonio, TX, USA.
John R KalmarDivision of Oral and Maxillofacial Pathology, The Ohio State University College of Dentistry, Columbus, OH, USA.
Sarah AguirreDivision of Oral and Maxillofacial Pathology, The University of Tennessee Health Science Center College of Dentistry, Memphis, TN, USA.
Jeffrey F KraneDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Jose Luis TapiaDepartment of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA.
Katalin KissDepartment of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Kitrina CordellDepartment of Diagnostic Sciences, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA.
Molly RosebushDepartment of Diagnostic Sciences, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA.
A William BarrettDepartment of Histopathology, Queen Victoria Hospital, Holtye Road, East Grinstead, West Sussex, RH19 3DZ, UK.
Dolphine OdaDepartment Oral & Maxillofacial Surgery, School of Dentistry, University of Washington, Seattle, WA, USA.
Adel AssaadDepartment of Pathology, Virginia Mason Hospital & Seattle Medical Center, Seattle, WA, USA.
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Fumi KawakamiDepartment of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan.
Masato NakaguroDepartments of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Ismail ZahirDepartment of Pathology Mount Sinai Brooklyn, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Kristina WakemanDepartment of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
Stephan IhrlerDERMPATH Muenchen, Munich, Germany.
Jacinthe ChenevertPathology Department, L'Hôtel-Dieu de Québec, Centre Hospitalier Universitaire de Québec, Laval University, Quebec, Canada.
Yi-Ling LinDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, USA.
William H WestraDepartment of Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Jeffrey GaganDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.
Lisa M RooperDepartment of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with a characteristic histologic and immunophenotypic profile and recurrent MEF2C-SS18 fusions. Because only six cases of MSA have been published, its complete clinicopathologic spectrum is unclear, and its biologic behavior has not been documented. Here, we present an updated and expanded experience of 24 MSA cases. All cases of MSA were obtained from the authors' files. Immunohistochemistry for S100, SOX10, p63, p40, SMA, calponin, and mammaglobin was performed. Molecular analysis was performed by targeted RNA sequencing, SS18 break apart fluorescence in situ hybridization, and/or reverse transcriptase polymerase chain reaction for MEF2C-SS18 fusion. Clinical follow-up was obtained from medical records. A total of 24 MSA cases were collected, from 13 women and 11 men, ranging from 17 to 83 years (mean 49.5 years). The vast majority (23 of 24) arose in the oral cavity, with the palate (n = 14) and buccal mucosa (n = 6) as the most frequent subsites. Tumors showed consistent histologic features including: (1) microcystic tubules, (2) flattened intercalated duct-like cells, (3) monotonous oval hyperchromatic nuclei, (4) abundant basophilic luminal secretions, (5) fibromyxoid stroma, and (6) circumscribed borders with subtle infiltration. The tumors were very consistently positive for S100 (24 of 24), p63 (24 of 24), and SOX10 (14 of 14) and negative for p40 (0 of 21), calponin (0 of 12) and mammaglobin (0 of 16), while SMA (4 of 20) was variable. MEF2C-SS18 fusion was demonstrated in 21 of 24 cases; in the remaining 3 cases with insufficient RNA, SS18 break apart FISH was positive. Treatment information was available in 17 cases, all of which were managed with surgery only. In 14 cases with follow-up (1-216 months, mean 30), no cases recurred or metastasized. MSA is a distinct salivary gland neoplasm with remarkably consistent clinical, histologic, immunophenotypic, and genetic features that generally behaves in an indolent manner following surgery alone. These observations solidify MSA as a unique, low-grade salivary gland carcinoma that warrants inclusion in the next version of the WHO classification of head and neck tumors.

Indexed as

ActinsAdenocarcinomaAdolescentAdultAgedAged, 80 and overCalcium-Binding ProteinsCalponinsFemaleHumansImmunohistochemistryMaleMicrofilament ProteinsMiddle AgedS100 ProteinsSalivary Gland NeoplasmsActinsCalcium-Binding ProteinsCalponinsMicrofilament ProteinsS100 ProteinsSOX10 protein, humanSOXE Transcription FactorsTP63 protein, humanTranscription FactorsTumor Suppressor ProteinsAdenocarcinoma not otherwise specifiedMEF2C-SS18Microsecretory adenocarcinomaSalivary gland neoplasms

Identifiers

PMID33982215
PMCPMC8633253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.