Evidence map›Paper›PMID 33982186›Full record

ArticleAbdominal radiology (New York)2021

Reproducibility of liver R2* quantification for liver iron quantification from cardiac R2* acquisitions.

M R Muehler, K Vigen, D Hernando, A Zhu, T J Colgan, S B Reeder

Abstract read

In one paragraph

Article in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Multicenter Reproducibility of Liver Iron Quantification with 1.5-T and 3.0-T MRI.Radiology · 2023
Article
Quantifying Liver Heterogeneity via R2*-MRI with Super-Paramagnetic Iron Oxide Nanoparticles (SPION) to Characterize Liver Function and Tumor.Cancers · 2022
Article
Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated RJournal of magnetic resonance imaging : JMRI · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M R MuehlerDepartment of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA. muhler@wisc.edu.ORCID http://orcid.org/0000-0003-4204-2084

K VigenDepartment of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA.

D HernandoDepartment of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA.

A ZhuDepartment of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA.

T J ColganDepartment of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA.

S B ReederDepartment of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA.

Funding

Confounder-Corrected Quantitative MRI Biomarkers of HepaticR01DK100651 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2017

$2.7M

MRI-based Quantitative Susceptibility Mapping of Hepatic Iron OverloadR01DK117354 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HERNANDO, DIEGO · 2018 to 2021

$2.3M

Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIR01DK083380 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2010 to 2013

$1.2M

Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018

$927k

NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01 DK100651NIDDK NIH HHS R01 DK117354

6 · The paper itself

Abstract

objectivesTo evaluate the reproducibility of liver R2* measurements between a 2D cardiac ECG-gated and a 3D breath-hold liver CSE-MRI acquisition for liver iron quantification.

methodsA total of 54 1.5 T MRI exams from 51 subjects (18 women, 36 men, age 35.2 ± 21.8) were included. These included two sub-studies with 23 clinical MRI exams from 19 patients identified retrospectively, 24 participants with known or suspected iron overload, and 7 healthy volunteers acquired prospectively. The 2D cardiac and the 3D liver R2* maps were acquired in the same exam. Either acquisitions were reconstructed using a complex R2* algorithm that accounts for the presence of fat and residual phase errors due to eddy currents. Data were analyzed using colocalized ROIs in the liver.

resultsLinear regression analysis demonstrated high Pearson's correlation and Lin's concordance coefficient for the overall study and both sub-studies. Bland-Altman analysis also showed good agreement, except for a slight increase of the mean R2* value above ~ 400 s

conclusionsThe results demonstrate that R2*-measurements in the liver are feasible using 2D cardiac R2* maps compared to 3D liver R2* maps as the reference. Liver R2* may be underestimated for R2* > 400 s

Indexed as

IronIron OverloadAdolescentAdultFemaleHumansLiverMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsRetrospective StudiesYoung AdultIron2D cardic3D liverLiver ironR2* mapping

Identifiers

PMID33982186

DOI10.1182/blood-2004-10-3982

PMCPMC8346410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.