Evidence map›Paper›PMID 33982152›Full record

ReviewTranslational stroke research2022

Extracellular Vesicle Application as a Novel Therapeutic Strategy for Ischemic Stroke.

Yiyang Li, Bowen Liu, Ying Chen, Xingping Quan, Yan Han, Ying Zheng, Yonghua Zhao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Extracellular Vesicles as a Potential Therapy for Stroke.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiyang Li *State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China.
Bowen Liu *State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China.
Ying ChenFaculty of Medicine, Macau University of Science and Technology, Macao, 999078, SAR, China.
Xingping QuanState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China.
Yan HanState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China.
Ying ZhengState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China. Yzheng@um.edu.mo.
Yonghua ZhaoState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China. yonghuazhao@um.edu.mo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke (IS) accounts for most of the cases of stroke onset, and due to short therapeutic time window for thrombolysis and numerous limited treatment measures and contraindications, lots of patients cannot receive satisfying therapeutic effects resulting in high disability and mortality worldly. In recent years, extracellular vesicles (EVs), as nanosized membrane-structured vesicles secreted from almost all cells, especially from stem/progenitor cells, have been reported to exert significant beneficial effects on IS from multiple approaches and notably ameliorate neurological outcome. Moreover, based on nano-size and lipid bilayer structure, EVs can easily penetrate the blood-brain barrier and migrate into the brain. In this review, we mainly systematically summarize the therapeutic effects of EVs on IS and explore their potential applications. Simultaneously, we also discuss administration routines, dosages, experimental observation time, and some key issues of EV application during IS treatment. It contributes to a comprehensive understanding of the progress of EV treatment for IS and providing confident evidence for further EV clinical application widely.

Indexed as

Extracellular VesiclesIschemic StrokeStrokeBlood-Brain BarrierBrainHumansApplicationExtracellular vesiclesIschemic strokeMechanismsTherapeutic effects

Identifiers

PMID33982152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.