ArticleJournal of affective disorders reports2020
Differential Impact on Isolated REM Sleep without Atonia by Varying Antidepressant Therapies.
Article in Journal of affective disorders reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Post-intracerebral hemorrhage depression comorbid with obstructive sleep apnea and REM sleep behavior disorder: a case report and literature review.Frontiers in psychiatry · 2026Article
- Ikelos-Rating Scale: Validation of a Behavioural Severity Marker in REM Sleep Behaviour Disorder.Journal of sleep research · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundREM sleep without atonia (RSWA) is characterized by increased phasic or tonic muscle activity in electromyography channels during polysomnography and usually causes REM sleep behaviour disorder, but RSWA also exists within healthy populations without dream-enactment behaviour, especially in psychiatric populations receiving antidepressant therapies. Evidence for differential impact of antidepressants on RSWA, and whether RSWA persists or resolves following changes in antidepressant therapy, remains limited. CASE: We present a 56-year-old woman with depression undergoing 3 polysomnograms while receiving 3 different distinct antidepressants. Her first polysomnogram demonstrated elevated REM sleep without atonia while receiving a tricyclic antidepressant. Following a switch to fluoxetine, her second polysomnogram showed greater elevation of REM sleep without atonia After a subsequent therapeutic switch to buproprion, a third polysomnogram showed interval decrease in RSWA amounts, lower than the initial levels found during tricyclic antidepressant administration. RESULTS/OUTCOMES: A switch from fluoxetine to bupropion was associated with markedly reduced RSWA amounts. CONCLUSION/
interpretationThe polysomnography findings in this case suggest that the type of antidepressant treatment differentially impacts levels of RSWA. The potential importance and implication to practicing psychiatrists is that bupropion, with selective action on dopamine reuptake rather than serotoninergic or acetylcholinergic neurotransmission, may have lesser tendency toward increasing REM sleep muscle activity levels. Additional prospective studies comparing polysomnographic RSWA in psychiatric populations are needed. DECLARATION OF INTEREST/
fundingThe authors have no financial support, off-label use, or conflict of interest to declare.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.