ArticleiScience2021
EEG alterations during wake and sleep in mild cognitive impairment and Alzheimer's disease.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The EEG analysis and identification of Alzheimer's disease: a review.Frontiers in aging neuroscience · 2025Pooled it
- Capturing silent oxidative stress in early Alzheimer's disease: prediction of CSF biomarkers from sleep qEEG data.GeroScience · 2026Article
- Sleep-like slow waves during resting-state: A promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- EEG Brain Rhythms During Resting-State Wakefulness and Sleep in Elderly Expert Meditators.Journal of sleep research · 2026Article
- Article
- Altered rhythmic and arrhythmic electroencephalographic activity during non-rapid eye movement sleep in amnestic mild cognitive impairment.Brain communications · 2026Article
- Integrating memory-guided saccades and EEG for MCI screening: a multimodal LASSO modeling approach.Frontiers in aging neuroscience · 2026Article
- REM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in Aging.bioRxiv : the preprint server for biology · 2025Article
- Investigating Gamma Frequency Band PSD in Alzheimer's Disease Using qEEG from Eyes-Open and Eyes-Closed Resting States.Journal of clinical medicine · 2025Article
- Time-Frequency Domain Analysis of Quantitative Electroencephalography as a Biomarker for Dementia.Diagnostics (Basel, Switzerland) · 2025Review
- Disruption of sleep macro- and microstructure in Alzheimer's disease: overlaps between neuropsychology, neurophysiology, and neuroimaging.GeroScience · 2025Article
- Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening.npj aging · 2025Article
- Tauopathy after long-term cervical lymphadenectomy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Resting-State EEG Power Spectral Density Analysis Between Healthy and Cognitively Impaired Subjects.Brain sciences · 2025Article
- Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Nocturnal sleep dynamics alterations in the early stages of behavioral variant frontotemporal dementia.Sleep · 2025Article
- Naps, night-time sleep and cognitive function among middle-aged and older people in China.PloS one · 2025Article
- A valuation based theory of learning's origin and development.Frontiers in systems neuroscience · 2025Article
- From Gut Microbiota to Brain Waves: The Potential of the Microbiome and EEG as Biomarkers for Cognitive Impairment.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Alzheimer's disease (AD) undergo a slowing of waking electroencephalographic (EEG) rhythms since prodromal stages, which could be ascribed to poor sleep quality. We examined the relationship between wake and sleep alterations by assessing EEG activity during sleep and (pre-sleep/post-sleep) wakefulness in AD, mild cognitive impairment (MCI) and healthy controls. AD and MCI show high sleep latency and less slow-wave sleep. Reduced sigma activity characterizes non-rapid eye movement (NREM) sleep, reflecting sleep spindles loss. The EEG slowing characterizes REM sleep and wakefulness of AD and MCI, with strong correlations among the two phenomena suggesting common neuropathological mechanisms. Evening-to-morning variations in waking EEG revealed the gradual disappearance in MCI and AD of overnight changes in delta activity, indicating a progressive decay of sleep restorative functions on diurnal activity that correlates with the impairment of sleep high-frequency activity in AD. Our findings support a linkage between wake and sleep alterations, and the importance of sleep-related processes in Alzheimer's disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.