ArticleCurrent developments in nutrition2021
Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock.
Article in Current developments in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Research progress and future directions in circadian rhythms for uterine‑related diseases (Review).Molecular medicine reports · 2026Review
- Effects of Intermittent Fasting on Female Reproductive Function: A Review of Animal and Human Studies.Current nutrition reports · 2024Review
- Comparison of the Effects of Inappropriate Meal Timing-Induced and Genetic Models of Circadian Clock Disruption on Uterine mRNA Expression Profiles.The Journal of nutrition · 2024Article
- Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.BMC pregnancy and childbirth · 2023Article
- The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship.International journal of molecular sciences · 2023Review
- Effects of whole-body vibration on reproductive physiology in a rat model of whole-body vibration.Journal of toxicology and environmental health. Part A · 2022Article
- Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study.Nutrition journal · 2022Article
- Uterine Deletion ofInternational journal of molecular sciences · 2022Article
- Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice.Medicina (Kaunas, Lithuania) · 2022Article
- Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice.Frontiers in nutrition · 2022Article
- Article
- Influence of lifestyle and the circadian clock on reproduction.Reproductive medicine and biologyReview
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkipping breakfast is associated with dysmenorrhea in young women. This suggests that the delay of food intake in the active phase impairs uterine functions by interfering with circadian rhythms.
objectivesTo examine the relation between the delay of feeding and uterine circadian rhythms, we investigated the effects of the first meal occasion in the active phase on the uterine clock.
methodsZeitgeber time (ZT) was defined as ZT0 (08:45) with lights on and ZT12 (20:45) with lights off. Young female mice (8 wk of age) were divided into 3 groups: group I (ad libitum consumption), group II (time-restricted feeding during ZT12-16, initial 4 h of the active period), and group III (time-restricted feeding during ZT20-24, last 4 h of the active period, a breakfast-skipping model). After 2 wk of dietary restriction, mice in each group were killed at 4-h intervals and the expression profiles of uterine clock genes,
resultsqPCR and western blot analyses demonstrated synchronized circadian clock gene expression within the uterus. Immunohistochemical analysis confirmed that BMAL1 protein expression was synchronized among the endometrium and myometrium. In groups I and II, mRNA expression of
conclusionsThis study is the first to indicate that time-restricted feeding regulates a circadian rhythm of the uterine clock that is synchronized throughout the uterine body. These findings suggest that the uterine clock system is a new candidate to explain the etiology of breakfast skipping-induced uterine dysfunction.
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