ArticlePain reports2021
Prevalence of postamputation pain and its subtypes: a meta-analysis with meta-regression.
Article in Pain reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of PostAmputation Pain With Targeted Muscle Reinnervation: A National, Multicenter, Randomized, Sham-controlled Superiority Trial, Comparing Standard Neurectomy With Targeted Muscle Reinnervation in Amputations of the Lower Extremities
Results of Nerve Surgery to Treat PostAmputation Pain (TreatPAP): a Prospective Study
Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The prevalence of post-amputation pain in amputees: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- Perioperative Pain Management for Major Limb Amputation - A Systematic-Narrative Hybrid Review.Current pain and headache reports · 2025Pooled it
- Phantom Limb Pain and Painful Neuroma After Dysvascular Lower-Extremity Amputation: A Systematic Review and Meta-Analysis.Vascular and endovascular surgery · 2024Pooled it
- Trial
- Article
- Article
- Agreement between Patient-reported Pain Medication Use and Electronic Medical Record Data in Surgical Amputation Patients.Plastic and reconstructive surgery. Global open · 2023Article
- Altered cortical thickness and structural covariance networks in upper limb amputees: A graph theoretical analysis.CNS neuroscience & therapeutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe inconsistent use of standardized approaches for classifying postamputation pain (PAP) has been a barrier to establishing its prevalence.
objectivesThe primary objective of this systematic review and meta-analysis is to determine the prevalence of nontraumatic lower-extremity PAP using an established taxonomy. The secondary objective is to determine the prevalence of PAP subtypes, including phantom limb pain and residual limb pain (RLP).
methodsAn a priori protocol was registered, and a database search was conducted by a reference librarian. Randomized trials and uncontrolled studies were eligible for inclusion. The risk of bias was assessed using a tool developed for uncontrolled studies. A total of 2679 studies were screened, and 13 studies met inclusion criteria (n = 1063).
resultsThe sources of risk of bias included selection bias and, to a lesser extent, whether the outcome was adequately ascertained. Two studies reported the prevalence of PAP and the pooled prevalence was 61% (95% confidence interval [CI], 33%-86%) with high heterogeneity (I
conclusionsThe prevalence of PAP is high in patients with nontraumatic lower-extremity amputations. Ongoing research that uses a taxonomy for PAP is needed to fully delineate the prevalence of PAP subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.