Evidence map›Paper›PMID 33981899›Full record

ArticleHeliyon2021

Astrocyte reactivity in spinal cord and functional impairment after tendon injury in rats.

Áurea Gabriela Rodrigues Mendes, Gabriel Gomes Vilar de Sousa, Martha de Souza França, Carlos Alberto Marques de Carvalho, Evander de Jesus Oliveira Batista, Adelaide da Conceição Fonseca Passos, Karen Renata Herculano Matos Oliveira, Anderson Manoel Herculano, Suellen Alessandra Soares de Moraes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Total rupture of Achilles tendon induces inflammatory response and glial activation on the spinal cord of mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Áurea Gabriela Rodrigues MendesInstituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Gabriel Gomes Vilar de SousaInstituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Martha de Souza FrançaInstituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Carlos Alberto Marques de CarvalhoDepartamento de Patologia, Universidade do Estado do Pará, Belém, Pará, Brazil.
Evander de Jesus Oliveira BatistaNúcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil.
Adelaide da Conceição Fonseca PassosInstituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Karen Renata Herculano Matos OliveiraInstituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Anderson Manoel HerculanoInstituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Suellen Alessandra Soares de MoraesInstituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
Universidade Federal do Pará · BRUniversidade do Estado do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocyte reactivity in the spinal cord may occur after peripheral neural damage. However, there is no data to report such reactivity after Achilles tendon injury. We investigate whether changes occur in the spinal cord, mechanical sensitivity and gait in two phases of repair after Achilles tendon injury. Wistar rats were divided into groups: control (CTRL, without rupture), 2 days post-injury (RUP2) and 21 days post-injury (RUP21). Functional and mechanical sensitivity tests were performed at 2 and 21 days post-injury (dpi). The spinal cords were processed, cryosectioned and activated astrocytes were immunostained by GFAP at 21 dpi. Astrocyte reactivity was observed in the L5 segment of the spinal cord with predominance in the white matter regions and decrease in the mechanical threshold of the ipsilateral paw only in RUP2. However, there was gait impairment in both RUP2 and RUP21. We conclude that during the acute phase of Achilles tendon repairment, there was astrocyte reactivity in the spinal cord and impairment of mechanical sensitivity and gait, whereas in the chronic phase only gait remains compromised.

Indexed as

Achilles tendonAstrocyte reactivityGaitMechanical sensitivityTendon injury

Identifiers

PMID33981899
PMCPMC8082259
OpenAlexW3154870391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.