ReviewBMJ open ophthalmology2021
Prevalence of keratoconus in persons with Down syndrome: a review.
Review in BMJ open ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Trial
- Genetics of Keratoconus: A Comprehensive Review.Genes · 2025Review
- Keratoconus: The Local Manifestation of a Systemic Disease?Journal of clinical medicine · 2025Review
- Socioeconomic and Demographic Disparities in Keratoconus Treatment.American journal of ophthalmology · 2025Article
- Individual Risk Assessment and Prognostication of Outcomes After Corneal Cross-Linking.Journal of ophthalmology · 2025Article
- Scheimpflug Tomographic Indices for Classifying Normal, Down Syndrome and Clinical Keratoconus in Pediatric Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Gene Expression Studies in Down Syndrome: What Do They Tell Us about Disease Phenotypes?International journal of molecular sciences · 2024Review
- Mendelian Randomisation Analysis of Causal Association between Lifestyle, Health Factors, and Keratoconus.Bioengineering (Basel, Switzerland) · 2024Article
- Systemic and Ocular Associations of Keratoconus.Expert review of ophthalmology · 2024Article
- Systemic Associations with Keratoconus.Life (Basel, Switzerland) · 2023Review
- Ophthalmic manifestations in children with Down Syndrome in Bogotá, Colombia.BMC ophthalmology · 2023Article
- The Ophthalmic Manifestations of Down Syndrome.Children (Basel, Switzerland) · 2023Review
- Wilson Disease Combined with Keratoconus: A Case Report.Beyoglu eye journal · 2023Article
- The Underlying Relationship between Keratoconus and Down Syndrome.International journal of molecular sciences · 2022Review
- Techniques in pediatric refractive surgery.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeKeratoconus is a vision-threatening condition, and there is a need for knowledge about the occurrence in subgroups of the population. The progression of the disease can be effectively stopped, and vision may be restored, if keratoconus is diagnosed at an early stage. The purpose of this review was to evaluate the literature of the prevalence of keratoconus in persons with Down syndrome.
methodsWe conducted a literature review of keratoconus prevalence in persons with Down syndrome. A thorough search was performed in Pubmed (Medline), and the quality of evidence was evaluated.
resultsThe literature review identified 20 relevant studies, which reported keratoconus in 0%-71% of persons with Down syndrome. These studies varied greatly in design, patient selection, sample sizes and mean age, and the quality of evidence concerning estimates for the prevalence of keratoconus was generally evaluated as low. Most studies that included adults reported high prevalences of keratoconus-in many studies more than 10-fold the prevalence in the general population. No large screening studies in persons with Down syndrome were identified.
conclusionsThe present review showed that the prevalence of keratoconus in persons with Down syndrome is higher than in the general population. However, estimates from previous studies vary widely. Screening for keratoconus in this group should be considered.
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Registered trials
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