Evidence map›Paper›PMID 33981789›Full record

ArticleMovement disorders clinical practice2021

Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease.

Kristina Rosqvist, Per Odin, Stefan Lorenzl, Wassilios G Meissner, Bastiaan R Bloem, Joaquim J Ferreira, Richard Dodel, Anette Schrag, Care of Late Stage Parkinsonism (CLaSP) Consortium

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In one paragraph

Article in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Clinical trials in late-stage Parkinson's disease.Journal of Parkinson's disease · 2026
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  8. Factors associated with self-rated health in people with late-stage parkinson's and cognitive impairment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristina RosqvistDivision of Neurology, Department of Clinical Sciences Lund, Faculty of Medicine Lund University Lund Sweden.ORCID https://orcid.org/0000-0002-3861-8012
Per OdinDivision of Neurology, Department of Clinical Sciences Lund, Faculty of Medicine Lund University Lund Sweden.ORCID https://orcid.org/0000-0002-0756-7478
Stefan LorenzlInterdisciplinary Center for Palliative Medicine and Clinic for Neurology University of Munich, the Großhadern clinic Munich Germany.
Wassilios G MeissnerDepartment of Neurology the University Hospital of Bordeaux Bordeaux France.ORCID https://orcid.org/0000-0003-2172-7527
Bastiaan R BloemDepartment of Neurology, Centre of Expertise for Parkinson & Movement Disorders Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour Nijmegen The Netherlands.ORCID https://orcid.org/0000-0002-6371-3337
Joaquim J FerreiraFaculty of Medicine Molecular Medicine Institute, the University of Lisbon Lisbon Portugal.ORCID https://orcid.org/0000-0003-3950-5113
Richard DodelDepartment of Geriatric Medicine University Hospital Essen Essen Germany.
Anette SchragQueen Square Institute of Neurology University College London London UK.ORCID https://orcid.org/0000-0002-9872-6680
Care of Late Stage Parkinsonism (CLaSP) Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD).

objectiveTo assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision.

methodsThe Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. The current study analyzed data of 401 patients from 6 European countries in whom HRQoL was assessed with the 8-item PD Questionnaire in patients without dementia. Factors potentially associated with HRQoL were assessed and examined in linear regression analyses.

resultsBetter HRQoL was associated with living at home, greater independence in activities of daily living (Schwab and England Scale), less severe disease (Hoehn and Yahr stage), better motor function (Unified PD Rating Scale Part III), and lower non-motor symptoms burden (Non-Motor Symptoms Scale [NMSS]) across all NMSS domains. Having a PDspecialist as physician for PD, contact with a PDnurse, and no hospital admission during the past 3 months were associated with better HRQoL, but having seen a physiotherapist or occupational therapist was associated with worse HRQoL.

conclusionsThe results emphasize the importance of optimizing treatment for motor and multiple non-motor symptoms to improve HRQoL in patients with late-stage PD. PD-specific health care resources, particularly PDnurses, are likely important in addressing issues to improve HRQoL in this population. Worse HRQoL in those who had recently seen a physiotherapist or occupational therapist may reflect referral based on factors not measured in this study.

Indexed as

health carehealth‐related quality of lifelatestageParkinsonʼs disease

Identifiers

PMID33981789
PMCPMC8088114

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.