ArticleBioMed research international2021
The Evolving Epidemiology of Elderly with Degenerative Valvular Heart Disease: The Guangzhou (China) Heart Study.
Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Trends in Sudden Cardiac Death Related Mortality in Adults in the United States: A CDC WONDER Database Analysis, 1999-2020.Clinical cardiology · 2025Article
- Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Global Prevalence of Mitral Regurgitation: A Systematic Review and Meta-Analysis of Population-Based Studies.Journal of clinical medicine · 2025Review
- Development and validation of a prediction model for heart failure in patients with heart valvular regurgitation.ESC heart failure · 2024Article
- Valvular heart disease and cardiomyopathy in China: epidemiology and current treatments.Journal of geriatric cardiology : JGC · 2024Article
- Transcatheter aortic valve replacement in China - a review of the available evidence.AsiaIntervention · 2024Review
- Relationship between valvular structure and biochemical indices of non-valvular atrial fibrillation and senile degenerative valvular heart disease.Journal of thoracic disease · 2023Article
- Prospective cohort study of characteristics and sex differences in elderly patients with degenerative valvular disease.BMJ open · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe present study was aimed at investigating the prevalence, incidence, progression, and prognosis of degenerative valvular heart disease (DVHD) in permanent residents aged ≥65 years from Guangzhou, China.
methodsThis was a prospective study based on community population. Over a 3-year span, we conducted repeated questionnaires, blood tests, and echocardiographic and electrocardiogram examinations (2018) of a random sample of initially 3538 subjects.
resultsThe prevalence of DVHD increased with age, average values being 30.6%, 49.2%, and 62.9% in 65-74, 75-84, and ≥85 years of age, respectively. The incidence rate was 1.7%/year. Aortic stenosis was the result of DVHD, and the mean transvalvular pressure gradient increased by 5.6 mmHg/year. The increase of mild aortic stenosis was lower than that of more severe disease, showing a nonlinear development of gradient, but with great individual variations. Mortality was significantly increased in the DVHD group (HR = 2.49). Risk factors for higher mortality included age (
conclusionsDVHD was highly prevalent among residents in southern China. With the progression of the disease, the mean transvalvular pressure gradient accelerated. DVHD was an independent predictor of death, and the mortality was higher in those with older age, renal insufficiency, atrial fibrillation, mitral regurgitation, and tricuspid regurgitation.
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