Evidence map›Paper›PMID 33981763›Full record

ArticleMicrobial cell (Graz, Austria)2021

Too much of a good thing: Overproduction of virulence factors impairs cryptococcal pathogenicity.

Julia C V Reuwsaat, Tamara L Doering, Livia Kmetzsch

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial cell (Graz, Austria), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Mechanisms and Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2024
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Julia C V ReuwsaatMolecular Biology of Pathogens Laboratory, Biotechnology Center, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Livia KmetzschMolecular Biology of Pathogens Laboratory, Biotechnology Center, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BRWashington University in St. Louis · US

Funding

CAPSULE REGULATION AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANSR01AI087794 · NIAID · WASHINGTON UNIVERSITY · PI BRENT, MICHAEL R, DOERING, TAMARA L · 2011 to 2020
$4.1M
Cryptococcal factors in host cell interactionsR21AI140979 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2019
$428k
NIAID NIH HHS R01 AI087794NIAID NIH HHS R21 AI140979
6 · The paper itself

Abstract

The regulation of virulence factor production and deployment is crucial for the establishment of microbial infection and subsequent pathogenesis. If these processes are not properly coordinated, the infecting pathogen is less likely to both survive the immune response and cause damage to the host. One key virulence factor of the opportunistic fungal pathogen

Indexed as

capsuleCryptococcus neoformansfungal pathogenesisPdr802Titan cellsvirulence factors

Identifiers

PMID33981763
PMCPMC8080896
OpenAlexW3158333247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.