Evidence map›Paper›PMID 33981465›Full record

ArticleEuropean journal of chemistry (Print)2019

Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids.

Constantinos G Neochoritis, Tryfon Zarganes-Tzitzikas, Michaela Novotná, Tatiana Mitríková, Zefeng Wang, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of chemistry (Print), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Constantinos G NeochoritisDepartment of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
Tryfon Zarganes-TzitzikasDepartment of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
Michaela NovotnáDepartment of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
Tatiana MitríkováDepartment of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
Zefeng WangDepartment of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
Katarzyna KurpiewskaFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Justyna Kalinowska-TłuścikFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Alexander DömlingDepartment of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
University of Groningen · NLJagiellonian University · PLUniversity of Crete · GR

Funding

Real-time discovery of inhibitors among billion compounds for preview and downloadR01GM097082 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMACHO, CARLOS J. · 2011 to 2020
$2.5M
NIGMS NIH HHS R01 GM097082
6 · The paper itself

Abstract

Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.

Indexed as

BoronC-C couplingMulticomponent reactionsStructure elucidationUgi reaction

Identifiers

PMID33981465
PMCPMC8112803
OpenAlexW2967998006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.