Evidence map›Paper›PMID 33981183›Full record

ArticleEuropean journal of organic chemistry2019

Structure and Reactivity of Glycosyl Isocyanides.

Constantinos G Neochoritis, Ehsan Ghonchepour, Maryam Kazemi Miraki, Tryfon Zarganes-Tzitzikas, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Glycoconjugates via phosphorus ylides.European journal of organic chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Constantinos G NeochoritisDepartment of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Ehsan GhonchepourDepartment of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Maryam Kazemi MirakiDepartment of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Tryfon Zarganes-TzitzikasDepartment of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Katarzyna KurpiewskaFaculty of Chemistry, Jagiellonian University, Ingardena Street 3, 30-060 Kraków, Poland.
Justyna Kalinowska-TłuścikFaculty of Chemistry, Jagiellonian University, Ingardena Street 3, 30-060 Kraków, Poland.
Alexander DömlingDepartment of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
University of Groningen · NLJagiellonian University · PL

Funding

Real-time discovery of inhibitors among billion compounds for preview and downloadR01GM097082 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMACHO, CARLOS J. · 2011 to 2020
$2.5M
NIGMS NIH HHS R01 GM097082
6 · The paper itself

Abstract

3D structural information was obtained from mono-, di- and trisaccharide formamide and isocyanide derivatives by analysis of their X-ray crystal structure and NMR spectroscopy. The isocyanide anomeric effect was observed. Data mining of the Cambridge Structural Database (CSD) was performed and statistically confirmed our findings. Application of the glycoside isocyanides in the synthesis of novel glycoconjugates as drug-like scaffolds by MCR chemistry underscores the usefulness of the novel building blocks.

Indexed as

AmidesAnomeric effectIsocyanidesMulticomponent reactionsOligosaccharides

Identifiers

PMID33981183
PMCPMC8112802
OpenAlexW2900591693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.