Evidence map›Paper›PMID 33981155›Full record

ArticleJournal of inflammation research2021

Investigation of Wound Healing and Anti-Inflammatory Activities of Solvent Fractions of 80% Methanol Leaf Extract of

Teklie Mengie, Solomon Mequanente, Dereje Nigussie, Belete Legesse, Eyasu Makonnen

RetractedAbstract readRetracted Publication
In one paragraph

Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. GC-MS/MS Analysis and Wound Repair Potential ofCurrent pharmaceutical biotechnology · 2025
    Article
  3. International journal of nanomedicine · 2025
    Article
  4. Review
  5. Green Synthesis of Zinc Oxide Nanoparticles fromInternational journal of nanomedicine · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Evaluation of Antidiarrheal Activity of 80% Methanol Extract and Solvent Fractions of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  10. Article
  11. Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Teklie MengieDepartment of Pharmacy, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0002-4578-5388
Solomon MequanenteDepartment of Pharmacology & Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-7844-3771
Dereje NigussieVaccines and Diagnostic Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-2145-5990
Belete LegesseCenter for Innovative Drug Development & Therapeutics Trial in Africa (CDT-Africa), College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-1402-9221
Eyasu MakonnenDepartment of Pharmacology & Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe various fractions of leaves of

methodsThe 80% methanol leaf extract of

resultsThe 10% w/w chloroform fraction ointment revealed a high percentage of wound contraction and reduced period of epithelialization (p <0.01). Chloroform fraction was also found to be the most active fraction, which demonstrated the maximum percentage inhibition of edema (52.50%; p <0.01) and transudative and proliferative component of chronic inflammation (37.52 and 52.81%; p <0.01), which was comparable to indomethacin.

conclusionData obtained from this study collectively indicated that a chloroform fraction of 80% methanol leaf extract of

Indexed as

Achyranthes asperacarrageenan-induced paw edemacotton pellet granulomawound healing

Identifiers

PMID33981155
PMCPMC8109023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.