Evidence map›Paper›PMID 33981040›Full record

ArticleNature2021

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.

Jie Yu, Prashant Rao, Sarah Clark, Jaba Mitra, Taekjip Ha, Eric Gouaux

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
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  5. Review
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  10. Article
  11. Trafficking of the human NaProtein science : a publication of the Protein Society · 2026
    Article
  12. Article
  13. Article
  14. Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.Protein science : a publication of the Protein Society · 2026
    Article
  15. From Atoms to Neuronal Spikes: A Multiscale Simulation Framework.Journal of chemical theory and computation · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. From Atoms to Neuronal Spikes: A Multi-Scale Simulation Framework.bioRxiv : the preprint server for biology · 2025
    Article
  20. "Design principles of a membrane-spanning ubiquitin ligase".bioRxiv : the preprint server for biology · 2025
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jie Yu *Vollum Institute, Oregon Health & Science University, Portland, OR, USA.
Prashant Rao *Vollum Institute, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-0132-5571
Sarah ClarkVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Jaba MitraDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0001-6569-6203
Taekjip HaDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2195-6258
Eric GouauxVollum Institute, Oregon Health & Science University, Portland, OR, USA. gouauxe@ohsu.edu.ORCID http://orcid.org/0000-0002-8549-2360
Oregon Health & Science University · USHoward Hughes Medical Institute · USJohns Hopkins University · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
3D STRUCTURE/FUNCTION OF LIGAND GATED ION CHANNELSR01NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 1999 to 2024
$6.7M
Single Molecule Studies of Nucleic Acids RemodelingR35GM122569 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Taekjip Ha · 2017 to 2026
$3.5M
Octet Red384S10OD023413 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI BARR-GILLESPIE, PETER GORDON · 2017 to 2017
$318k
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM122569NIGMS NIH HHS U24 GM129547NIH HHS S10 OD023413NINDS NIH HHS R01 NS038631
6 · The paper itself

Abstract

AMPA-selective glutamate receptors mediate the transduction of signals between the neuronal circuits of the hippocampus

Indexed as

Allosteric RegulationAnimalsBinding SitesCalcium ChannelsCarrier ProteinsCryoelectron MicroscopyFemaleHippocampusMaleMembrane ProteinsMiceMice, Inbred C57BLMicroscopy, FluorescenceModels, MolecularNerve Tissue ProteinsReceptors, AMPACalcium ChannelsCarrier ProteinsCnih2 protein, mouseMembrane ProteinsNerve Tissue ProteinsReceptors, AMPASynDIG1 protein, mouseTARP gamma-8 protein, mouse

Identifiers

PMID33981040
PMCPMC8270219
OpenAlexW3163624776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.