ArticleNature2021
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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91citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
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Who cites it
91 citing papers in PubMed, 122 citations in OpenAlex.
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- An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.Nature cancer · 2026Article
- ALKBH5 activates creatine-driven thermogenesis by stabilizing CKB mRNA in response to cold.Nature metabolism · 2026Article
- Exercise and Fat: A Primer.Sports medicine - open · 2026Review
- Hypophosphatasia: Results of a Country-Wide Selective Screening Program Using NGS Technology as a First-Tier Test.International journal of molecular sciences · 2026Article
- Alternative Receptor Signaling for the Selective and Multifaceted Regulation of Human Brown Adipocytes.International journal of molecular sciences · 2026Review
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- Glycerol is a new ally for heat production and bone health.Nature metabolism · 2026Article
- Enhanced metabolic benefits of dietary methionine restriction in cold resistant hybrid UCP1-deficient mice.The Journal of nutritional biochemistry · 2026Article
- Article
- Proteomic and Super-Resolution Analyses of Murine Brown Adipocyte-Derived Extracellular Vesicles.Journal of extracellular biology · 2026Article
- Advances in research on thermogenic substances.Journal of physiological anthropology · 2026Review
- ATP synthase is a promising target for identifying activated and non-activated adipose tissues.Nature communications · 2026Article
- Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.Nature metabolism · 2026Article
- The skeletal muscle-adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management.Experimental physiology · 2026Review
- Hypophosphatasia-pathophysiological understanding, preclinical data looking beyond the skeleton, and upcoming treatments.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Review
- Integrating bile acid metabolism into precision nutrition strategies for improved swine performance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Morphometric and hormonal correlations in high- and low-yield baizi geese during off-season production.Poultry science · 2026Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 4 institutions in 2 countries.
Yizhi SunDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5911-1117
Janane F RahbaniGoodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-4598-4683
Mark P JedrychowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Christopher L RileyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sara VidoniDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Dina BogoslavskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Bo HuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5599-6875
Phillip A DumesicDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Xing ZengDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Alex B WangDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8678-5205
Nelson H KnudsenDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Caroline R KimDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Anthony MarasciulloDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
José L MillánSanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Edward T ChouchaniDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9776-8790
Lawrence KazakGoodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-7591-2544
Bruce M SpiegelmanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-7658-4802
Harvard University · USDana-Farber Cancer Institute · USMcGill University Health Centre · CASanford Burnham Prebys Medical Discovery Institute · US
Funding
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MMOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2MDetermining mechanisms of the succinate thermogenesis pathways on UCP1-dependent and UCP1-independent thermogenesisR01DK123095 · NIDDK · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2019 to 2026
$4.2MCellular and Biochemical Pathways of Adipose Metabolism and ThermogenesisR01DK123228 · NIDDK · DANA-FARBER CANCER INST · PI SPIEGELMAN, BRUCE M. · 2020 to 2023
$2.1MThe Role of Mitochondrial TNAP in Adaptive ThermogenesisK01DK132455 · NIDDK · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI SUN, YIZHI · 2023 to 2025
$385kNHLBI NIH HHS T32 HL007208NIDCR NIH HHS R01 DE012889NIDDK NIH HHS K01 DK132455NIDDK NIH HHS R01 DK123095NIDDK NIH HHS R01 DK123228
Abstract
Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes
Indexed as
ThermogenesisAdipocytesAdipose Tissue, BrownAlkaline PhosphataseAnimalsCold TemperatureEnergy MetabolismHydrolysisMaleMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionMitochondriaMitochondrial ProteinsObesityPhosphocreatineAlkaline PhosphataseALPL protein, mouseMitochondrial ProteinsPhosphocreatine
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