ArticleNature2021
RNA transcripts stimulate homologous recombination by forming DR-loops.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 161 citations in OpenAlex.
- The nuclear pore complex as a spatial organizing hub for high-risk DNA lesions.Nucleus (Austin, Tex.) · 2026Review
- RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness.iScience · 2026Article
- Mechanisms and disease relevance of DNA break repair pathway choice.Nature reviews. Molecular cell biology · 2026Review
- PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.Cancer research · 2026Article
- Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα.Nature communications · 2026Article
- Transposase-Assisted Donor Tethering Boosts Large-Fragment HDR in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer.Cell reports · 2026Article
- HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair.Nature communications · 2026Article
- HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.Nature communications · 2026Article
- CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic acids research · 2026Article
- R-loops and D-loops: a delicate balance in genomic stability and instability.Cell communication and signaling : CCS · 2026Review
- Potential effects of endogenous RNA/DNA hybrids on CRISPR-Cas9-mediated homology-directed repair.Molecular therapy. Nucleic acids · 2026Article
- G quadruplex DNA facilitates a pervasive path to homologous recombination.bioRxiv : the preprint server for biology · 2026Article
- cGAS restricts PARP1-mediated microhomology-mediated end joining by suppressing poly-ADP-ribosylation.Cell death and differentiation · 2026Article
- R-PLA enables enhanced detection of R-loops in mammalian cells using proximity ligation.Cell reports methods · 2026Article
- RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence.Nucleic acids research · 2026Article
- TRF2-RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops.Nucleic acids research · 2026Article
- MDS/AML-associated DDX41 helicase facilitates homologous recombination repair by potentially resolving R-loops.Nucleic acids research · 2026Article
- R-loop processing via REXO4-RNaseH1-mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity.Science advances · 2026Article
- DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivation.PLoS biology · 2026Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Jian Ouyang *Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA. jouyang2@mgh.harvard.edu.
Tribhuwan Yadav *Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Jia-Min ZhangMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Haibo YangMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Esther RheinbayMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Hongshan GuoMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Daniel A HaberMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.ORCID http://orcid.org/0000-0003-1378-6551
Li LanMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.ORCID http://orcid.org/0000-0003-0383-6172
Lee ZouMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA. zou.lee@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-3094-1058
Harvard University · USHoward Hughes Medical Institute · US
Funding
Modeling Metastasis and Acquired Drug Resistance Using Circulating Tumor CellsR01CA129933 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel A. Haber · 2008 to 2026
$7.5MUnderstanding and targeting the DNA replication stress in cancer cellsR35CA263934 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Lee Zou · 2021 to 2026
$5.2MImplications of the ATR Checkpoint Kinase in Radiation and Targeted TherapiesR01CA197779 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ZOU, LEE · 2015 to 2020
$2.4MTranscription-Coupled Homologous Recombination upon DNA DamageR01GM118833 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAN, LI · 2016 to 2020
$1.6MImpacts of APOBECs on DNA replication, ATR checkpoint, and cancer therapyR01CA218856 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ZOU, LEE · 2018 to 2021
$1.5MUnderstanding and Targeting the R-Loop-Mediated DNA Damage Response at TelomeresR01CA282939 · NCI · DUKE UNIVERSITY · PI Li Lan · 2023 to 2026
$1.5MNCI NIH HHS R01 CA129933NCI NIH HHS R01 CA197779NCI NIH HHS R01 CA218856NCI NIH HHS R01 CA282939NCI NIH HHS R35 CA263934NIGMS NIH HHS R01 GM118833NIH HHS CA197779NIH HHS CA218856
Abstract
Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2 phases of the cell cycle
Indexed as
Transcription, GeneticBasic Helix-Loop-Helix ProteinsCell LineDNADNA-Binding ProteinsDNA Breaks, Double-StrandedDNA RepairGenesGenes, ReporterGreen Fluorescent ProteinsHomologous RecombinationHumansIn Vitro TechniquesRad51 RecombinaseR-Loop StructuresRNA-Binding ProteinsASCL1 protein, humanBasic Helix-Loop-Helix ProteinsDNADNA-Binding ProteinsGreen Fluorescent ProteinsRAD51AP1 protein, humanRAD51 protein, humanRad51 RecombinaseRNA-Binding ProteinsRNA, Messenger
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.