ArticleNature2021
Reconstruction of ancient microbial genomes from the human gut.
Open access · hybridAbstract readHistorical Article
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 2 syntheses or guidelines pooled it, 234 citations in OpenAlex.
- Meta-analysis of 22,710 human microbiome metagenomes defines an oral-to-gut microbial enrichment score and associations with host health and disease.Nature communications · 2025Pooled it
- Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions.Cell host & microbe · 2023Pooled it
- Alteration of the Gut-Lung Axis After Severe COVID-19 Infection and Modulation Through Probiotics: A Randomized, Controlled Pilot Study.Nutrients · 2024Trial
- Fermented food microbiome: influence on oral and gut microbiota, and human health.Nature reviews. Microbiology · 2026Review
- Gut microbes that trace ancient human journeys.Nature · 2026Article
- Article
- Comparing the Performance of Double-Stranded and Single-Stranded DNA Libraries for Ancient Oral Microbiome Reconstruction.Molecular ecology resources · 2026Article
- Functional Divergence in Gut Clostridia from Hadza Hunter-Gatherers Reveals Diet-Adapted Metabolic Machinery That Shapes Gut Ecology.bioRxiv : the preprint server for biology · 2026Article
- De novo assembly and authentication of ancient DNA metagenomes with nf-core/mag.PLoS computational biology · 2026Article
- Interactions at theMicrobiology (Reading, England) · 2026Review
- How Complex Dietary Fibers Can Be Used to Shape the Human Gut Microbiome Toward Reduced Inflammatory Potential: A Pilot Study.Molecules (Basel, Switzerland) · 2026Article
- Insights into demographic and cultural influences on the oral microbiome from historical Japanese dental calculus.Scientific reports · 2026Article
- Ancient Species Diversity and Niche Adaptation in Tannerella and Porphyromonas Revealed Through Pangenomics.Genome biology and evolution · 2026Article
- Review
- Segmented filamentous bacteria are worldwide human gut commensals.Nature communications · 2026Article
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Identification of antimicrobial peptides from ancient gut microbiomes.Nature communications · 2026Article
- Microbiome-inspired solutions to save human and planetary health.Frontiers in microbiology · 2026Review
- Integration of modern technologies to advance dietary assessment.Nature food · 2026Review
- Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 12 institutions in 6 countries.
Marsha C WibowoSection on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7678-5447
Zhen YangSection on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Maxime BorryDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.ORCID http://orcid.org/0000-0001-9140-7559
Alexander HübnerDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.
Kun D HuangCIBIO Department, University of Trento, Trento, Italy.
Braden T TierneySection on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7533-8802
Samuel ZimmermanSection on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Francisco Barajas-OlmosImmunogenomics and Metabolic Diseases Laboratory, Secretaría de Salud, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Cecilia Contreras-CubasImmunogenomics and Metabolic Diseases Laboratory, Secretaría de Salud, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Humberto García-OrtizImmunogenomics and Metabolic Diseases Laboratory, Secretaría de Salud, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-0453-980X
Angélica Martínez-HernándezImmunogenomics and Metabolic Diseases Laboratory, Secretaría de Salud, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Jacob M LuberSection on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Philipp KirstahlerResearch Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
Tre BlohmDepartment of Anthropology, University of Montana, Missoula, MT, USA.ORCID http://orcid.org/0000-0003-2845-6475
Francis E SmileyDepartment of Anthropology, Northern Arizona University, Flagstaff, AZ, USA.
Richard ArnoldPahrump Paiute Tribe and Consolidated Group of Tribes and Organizations, Pahrump, NV, USA.
Sonia A BallalDepartment of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Sünje Johanna PampResearch Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-6236-1763
Julia RussMorrison Microscopy Core Research Facility, Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Frank MaixnerInstitute for Mummy Studies, EURAC Research, Bolzano, Italy.
Omar Rota-StabelliResearch and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.ORCID http://orcid.org/0000-0002-0030-7788
Nicola SegataCIBIO Department, University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0002-1583-5794
Karl ReinhardSchool of Natural Resources, University of Nebraska-Lincoln, Lincoln, NE, USA.
Lorena OrozcoImmunogenomics and Metabolic Diseases Laboratory, Secretaría de Salud, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-5801-9180
Christina WarinnerDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.
Meradeth SnowDepartment of Anthropology, University of Montana, Missoula, MT, USA.
Steven LeBlancPeabody Museum of Archaeology and Ethnology, Harvard University, Cambridge, MA, USA.
Aleksandar D KosticSection on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA. aleksandar.kostic@joslin.harvard.edu.ORCID http://orcid.org/0000-0002-0837-4360
Joslin Diabetes Center · USSecretaria de Salud · MXFondazione Edmund Mach · ITHarvard University · USMax Planck Institute for the Science of Human History · DETechnical University of Denmark · DKUniversity of Montana · USUniversity of Nebraska–Lincoln · USBoston Children's Hospital · USEurac Research · ITNorthern Arizona University · USUniversity of Trento · IT
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MAmerican Heart Association-American Stroke AssociationEuropean Research CouncilNIDDK NIH HHS P30 DK036836
Abstract
Loss of gut microbial diversity
Indexed as
BiodiversityBiological EvolutionGastrointestinal MicrobiomeHost Microbial InteractionsAnti-Bacterial AgentsBacteriaChronic DiseaseDeveloped CountriesDeveloping CountriesDiet, WesternFecesGenome, BacterialHistory, AncientHumansIndustrial DevelopmentMethanobrevibacterAnti-Bacterial Agents
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.