ArticleNature2021
Thymic development of gut-microbiota-specific T cells.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Exploring the relationship between life course adiposity and sepsis: insights from a two-sample Mendelian randomization analysis.Frontiers in endocrinology · 2024Pooled it
- Gut microbiota translocation and dissemination in health: can it be beneficial and purposeful?Gut microbes · 2026Review
- Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.Gut microbes · 2026Article
- Review
- MaternalBiomedicines · 2026Article
- Maternal and infant gut microbiome.iMeta · 2026Review
- Application of Chinese Medicine in Treatment of Ulcerative Colitis and Elucidation of Relevant Mechanisms.Chinese journal of integrative medicine · 2026Review
- Tissue-resident colon macrophages shape the microbiome and regulate mucosal healing via ferroportin.Cell reports · 2026Article
- Gut commensal bifidobacteria are associated with restrained inflammatory reprogramming in human monocyte-derived dendritic cells.iScience · 2026Article
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- The advent of precision nutrigeroscience in cancer: from clinic towards molecular biology.Journal of advanced research · 2026Review
- Atlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways.Nature metabolism · 2026Article
- Review
- Review
- The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types.Nature immunology · 2026Article
- Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells.The Journal of experimental medicine · 2026Article
- Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells.Discovery immunology · 2026Review
- The triangular drivers of bone aging: mechanistic insights and therapeutic targets in cellular senescence, estrogen deficiency, and gut microenvironment dysregulation.Frontiers in cell and developmental biology · 2026Review
- Multifaceted regulation of thymic tolerance by pattern recognition cascades.Frontiers in immunology · 2026Review
- The gut-bone marrow axis in acute leukemia: an evidence-graded review of microbiota-immune crosstalk and therapeutic implications.Frontiers in cellular and infection microbiology · 2026Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
15 authors at 5 institutions in 2 countries.
Daniel F Zegarra-RuizImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0752-7238
Dasom V KimImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kendra NorwoodDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Myunghoo KimDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Wan-Jung H WuImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Fatima B Saldana-MoralesImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5192-5722
Andrea A HillDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Shubhabrata MajumdarImmunology Program, Baylor College of Medicine, Houston, TX, USA.
Stephanie OrozcoDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Rickesha BellDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
June L RoundDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Randy S LongmanDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Takeshi EgawaDepartment of Pathology, Washington University School of Medicine in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-7489-1051
Matthew L BettiniDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. Matt.Bettini@path.utah.edu.ORCID http://orcid.org/0000-0001-9479-657X
Gretchen E DiehlImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Diehlg1@mskcc.org.ORCID http://orcid.org/0000-0002-1841-2842
Memorial Sloan Kettering Cancer Center · USBaylor College of Medicine · USUniversity of Utah · USCornell University · USWashington University in St. Louis · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MThe transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6MOrchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions R01AI125264 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI GRETCHEN E DIEHL · 2017 to 2026
$4.1MTL1A Regulation of Group 3 Innate Lymphoid Cells in ColitisR01DK120985 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Randy S Longman · 2020 to 2026
$2.9MSelf-Reactive T Cell Development in Type 1 DiabetesR01DK114456 · NIDDK · UNIVERSITY OF UTAH · PI BETTINI, MATTHEW · 2018 to 2022
$1.9MHost-Microbiota Interactions in Crohn's Disease-associated SpondyloarthritisR01DK114252 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LONGMAN, RANDY S · 2018 to 2022
$1.9MMICROBIOTA SPECIFIC T CELL SELECTIONR01AI136963 · NIAID · UNIVERSITY OF UTAH · PI BETTINI, MATTHEW · 2019 to 2023
$1.9MCross-disciplinary Training in Immunology, Inflammation and Infectious DiseaseT32AI138945 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Tracey Jane Lamb, Matthew A Williams · 2018 to 2026
$1.6MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS HHSN272201300006CNIAID NIH HHS R01 AI125264NIAID NIH HHS R01 AI130152NIAID NIH HHS R01 AI136963NIAID NIH HHS T32 AI138945NIDDK NIH HHS R01 DK114252NIDDK NIH HHS R01 DK114456NIDDK NIH HHS R01 DK120985
Abstract
Humans and their microbiota have coevolved a mutually beneficial relationship in which the human host provides a hospitable environment for the microorganisms and the microbiota provides many advantages for the host, including nutritional benefits and protection from pathogen infection
Indexed as
AgingAnimalsAntigens, BacterialCX3C Chemokine Receptor 1Dendritic CellsDNA, BacterialEscherichia coliFemaleGastrointestinal MicrobiomeMaleMiceOrgan SpecificitySalmonellaSymbiosisThymus GlandT-LymphocytesAntigens, BacterialCX3C Chemokine Receptor 1Cx3cr1 protein, mouseDNA, Bacterial
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.