Evidence map›Paper›PMID 33981033›Full record

ArticleNature2021

Structures of telomerase at several steps of telomere repeat synthesis.

Yao He, Yaqiang Wang, Baocheng Liu, Christina Helmling, Lukas Sušac, Ryan Cheng, Z Hong Zhou, Juli Feigon

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A (Scientific) Lifetime Affair With Nucleic Acids.Journal of molecular biology · 2025
    Review
  9. A degenerate telomerase RNA directs telomeric DNA synthesis in lepidopteran insects.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Telomerase-Mediated Anti-Ageing Interventions.Sub-cellular biochemistry · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yao HeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1368-6422
Yaqiang WangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6822-4778
Baocheng LiuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Christina HelmlingDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Lukas SušacDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Ryan ChengDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Z Hong ZhouDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. hong.zhou@ucla.edu.ORCID http://orcid.org/0000-0002-8373-4717
Juli FeigonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. feigon@mbi.ucla.edu.ORCID http://orcid.org/0000-0003-3376-435X
University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Structural biology of telomerase and telomeresR35GM131901 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JULI FEIGON · 2019 to 2026
$5.7M
High-Resolution CryoEM Reconstruction of Large ComplexesR01GM071940 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, Z HONG · 2006 to 2025
$5.0M
West/Midwest Consortium for High-Resolution Cryo Electron MicroscopyU24GM116792 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AGBANDJE-MCKENNA, MAVIS, DOKLAND, TERJE · 2016 to 2020
$3.0M
HIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6M
Direct Detection Device for atomic resolution cryoEM of macromolecular complexesS10OD018111 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2014 to 2014
$598k
NCRR NIH HHS S10 RR023057NIGMS NIH HHS R01 GM071940NIGMS NIH HHS R35 GM131901NIGMS NIH HHS U24 GM116792NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129541NIH HHS S10 OD018111
6 · The paper itself

Abstract

Telomerase is unique among the reverse transcriptases in containing a noncoding RNA (known as telomerase RNA (TER)) that includes a short template that is used for the processive synthesis of G-rich telomeric DNA repeats at the 3' ends of most eukaryotic chromosomes

Indexed as

Cryoelectron MicroscopyAmino Acid MotifsBinding SitesDNAHumansModels, MolecularNucleotidesProtein BindingRibonucleoproteinsRNAShelterin ComplexTelomeraseTelomereTelomere-Binding ProteinsTemplates, GeneticTetrahymena thermophilaACD protein, humanDNANucleotidesPOT1 protein, humanRibonucleoproteinsRNAShelterin ComplexTelomerasetelomerase RNATelomere-Binding ProteinsTERT protein, human

Identifiers

PMID33981033
PMCPMC8857963
OpenAlexW3162473212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.