ArticleThe Journal of antibiotics2021
Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma.
Article in The Journal of antibiotics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ganodermataceae-current status, research, and development in Lower Mekong Basin.Frontiers in cellular and infection microbiology · 2025Review
- Bioactivities and industrial standardization status ofHeliyon · 2024Review
- Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments.Molecules (Basel, Switzerland) · 2024Article
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges.Drug design, development and therapy · 2024Review
- Natural Bio-Compounds fromAntioxidants (Basel, Switzerland) · 2023Review
- Progress Toward the Asymmetric de Novo Synthesis of Lanostanes: A Counter Biomimetic Cucurbitane-to-Lanostane Type Transformation.Tetrahedron · 2023Article
- A nostoxanthin-producing bacterium,Frontiers in microbiology · 2023Article
- Toward the Asymmetric de Novo Synthesis of Lanostanes: Construction of 7,11-Dideoxy-ΔThe Journal of organic chemistry · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium tuberculosis H37Ra than the lead natural lanostane (1). GA003 was also significantly active against the virulent strain (H37Rv) as well as extensively drug-resistant tuberculosis strains.
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Registered trials
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