ArticleMolecular psychiatry2021
Natural disaster stress during pregnancy is linked to reprogramming of the placenta transcriptome in relation to anxiety and stress hormones in young offspring.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Article
- Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit.Neuroscience bulletin · 2026Article
- Article
- Sex and Gender Influences on the Impacts of Disasters: A Rapid Review of Evidence.International journal of environmental research and public health · 2025Review
- Noncoding RNAs and their influence on maternal mental health: insights into perinatal depression: a review.Molecular biology reports · 2025Review
- Neurodevelopmental impact of mining-related contamination in children from the Sonora river basin.Frontiers in pediatrics · 2025Article
- Behavioral moderators ofFrontiers in psychiatry · 2025Article
- Placental transcriptomic signatures of prenatal and preconceptional maternal stress.Molecular psychiatry · 2024Article
- Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placentalStress (Amsterdam, Netherlands) · 2024Article
- Inheritance of Stress Responses via Small Non-Coding RNAs in Invertebrates and Mammals.Epigenomes · 2023Review
- Genome-wide neonatal epigenetic changes associated with maternal exposure to the COVID-19 pandemic.BMC medical genomics · 2023Observational
- Infants exposedmSphere · 2023Article
- Identification and prediction model of placenta-brain axis genes associated with neurodevelopmental delay in moderate and late preterm children.BMC medicine · 2023Article
- CANNABIS USE AND THE DEVELOPING BRAIN: HIGHS AND LOWS.Frontiers for young minds · 2023Article
- Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: stress in pregnancy study.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Association of maternal exposure to Superstorm Sandy and maternal cannabis use with development of psychopathology among offspring: the Stress in Pregnancy Study.BJPsych open · 2023Article
- The Effects of Climate Change on Mental Health.Deutsches Arzteblatt international · 2023Review
- Maternal Psychopathological Profile during Childbirth and Neonatal Development during the COVID-19 Pandemic: A Pre-Posttest Study.Behavioral sciences (Basel, Switzerland) · 2023Article
- Canada's Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes.International journal of environmental research and public health · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Prenatal stress can lead to long-term adverse effects that increase the risk of anxiety and other emotional disorders in offspring. The in utero underpinnings contributing to such phenotypes remain unknown. We profiled the transcriptome of placental specimens from women who lived through Hurricane Sandy during pregnancy compared to those pregnant during non-Sandy conditions. Following birth, longitudinal assessments were conducted in their offspring during childhood (~3-4 years old) to measure steroid hormones (in hair) and behavioral and emotional problems. This revealed a significant link between prenatal Sandy stress (PNSS) and child HPA dysfunction, evident by altered cortisol, dehydroepiandrosterone (DHEA), and cortisol:DHEA levels. In addition, PNSS was associated with significantly increased anxiety and aggression. These findings coincided with significant reorganization of the placental transcriptome via vascular, immune, and endocrine gene pathways. Interestingly, many of the most prominently altered genes were known to be uniquely expressed in syncytiotrophoblast (STB)-subtype of placental cells and harbored glucocorticoid response elements in promoter regions. Finally, several vascular development- and immune-related placental gene sets were found to mediate the relationship between PNSS and childhood phenotypes. Overall, these findings suggest that natural disaster-related stress during pregnancy reprograms the placental molecular signature, potentially driving long-lasting changes in stress regulation and emotional health. Further examination of placental mechanisms may elucidate the environment's contribution to subsequent risk for anxiety disorders later in life.
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