Evidence map›Paper›PMID 33980982›Full record

ArticleCommunications biology2021

A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells.

Margaret H O'Connor, Roshell Muir, Marita Chakhtoura, Michael Fang, Eirini Moysi, Susan Moir, Alison J Carey, Alyssa Terk, Carmen N Nichols, Talibah Metcalf and 4 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 25 citations in OpenAlex.

  1. High Frequency of Circulating IL-4RJournal of clinical and translational hepatology · 2026
    Article
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  8. Activation of CXCR3Journal of virology · 2025
    Article
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  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Margaret H O'ConnorThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-5127-8545
Roshell MuirThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Marita ChakhtouraThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Michael FangThe Department of Population and Quantitative Health Services, Case Western Reserve University, Cleveland, OH, USA.
Eirini MoysiTissue Analysis Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Susan MoirThe Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Alison J CareyThe Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-7610-5659
Alyssa TerkDepartment of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA.
Carmen N NicholsThe Department of Population and Quantitative Health Services, Case Western Reserve University, Cleveland, OH, USA.
Talibah MetcalfThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Constantinos PetrovasTissue Analysis Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5067-5810
Mark J CameronThe Department of Population and Quantitative Health Services, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-4768-4094
Virginie TardifThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA. virginie.san-martin-tardif@inserm.fr.ORCID 0000-0001-5604-6524
Elias K HaddadThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA. ee336@drexel.edu.ORCID 0000-0001-6924-4300
Drexel University · USCase Western Reserve University · USNational Institutes of Health · USSt. Christopher's Hospital for Children · USInserm · FR

Funding

Role of B Lymphocytes In HIV Infection And PathogenesisZIAAI000825 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MOIR, SUSAN · 2009 to 2025
$24.5M
Investigating the impact of helminth infection on microbioma composition and innate immunity generated during HepB vaccination. U19AI128910 · NIAID · DREXEL UNIVERSITY · PI HADDAD, ELIAS K · 2017 to 2021
$7.0M
Boosting anti-HIV immunity through manipulation of Tfh function.R01AI106482 · NIAID · VGTI FLORIDA · PI HADDAD, ELIAS K · 2013 to 2017
$2.8M
NIAID NIH HHS R01 AI106482NIAID NIH HHS U19 AI128910
6 · The paper itself

Abstract

Innate Lymphoid Cells (ILCs) are immune cells typically found on mucosal surfaces and in secondary lymphoid organs where they regulate the immune response to pathogens. Despite their key role in the immune response, there are still fundamental gaps in our understanding of ILCs. Here we report a human ILC population present in the follicles of tonsils and lymph nodes termed follicular regulatory ILCs (ILC

Indexed as

AdolescentAdultB-LymphocytesChildChild, PreschoolFemaleGerminal CenterHumansImmunity, InnateLymph NodesLymphocyte ActivationLymphocytesMalePalatine TonsilT Follicular Helper Cells

Identifiers

PMID33980982
PMCPMC8115650
OpenAlexW3161138478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.