SynthesisJournal of human hypertension2021
Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies.
Synthesis in Journal of human hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does non-surgical periodontal therapy improve biomarkers associated with cardiovascular disease? An umbrella review.Clinical oral investigations · 2025Pooled it
- Pre-procedural C-reactive protein levels and carotid or intracranial artery restenosis: A systematic review and meta-analysis.Atherosclerosis plus · 2026Article
- Biological Signatures of Inflammation Biomarkers Identified Using Data Reduction Methods in Adult Population: A Scoping Review Protocol.Health science reports · 2026Article
- Bladder cancer-induced CVD mortality: Role of CAPG protein.PloS one · 2026Article
- Article
- Association of GGT and hs-CRP with hypertension across different glycemic states in Saudi adults: A cross-sectional study.Heliyon · 2025Article
- Associations between inflammation and striatal dopamine D2-receptor availability in aging.Journal of neuroinflammation · 2025Article
- Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS).Clinical epigenetics · 2024Article
- A Narrative Review of the Role of Blood Biomarkers in the Risk Prediction of Cardiovascular Diseases.Cureus · 2024Review
- Biallelic TYR and TKFC variants in Egyptian patients with OCA1 and new expanded TKFC features.BMC genomics · 2024Article
- C-Reactive Protein and Long-Term Prognosis in Adult Patients with Congenital Heart Disease.Journal of clinical medicine · 2024Article
- Genetic Evidence for the Causal Association of Circulating Cytokines and Growth Factors With Coronary Artery Disease.Journal of the American Heart Association · 2024Article
- Elevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders.Cardiovascular diabetology · 2023Article
- Systemic and local vascular inflammation and arterial reactive oxygen species generation in patients with advanced cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Article
- C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors.Journal of clinical medicine · 2022Article
- Immunosenescence in Aging-Related Vascular Dysfunction.International journal of molecular sciences · 2022Article
- Cardiovascular risk assessment in periodontitis patients and controls using the European Systematic COronary Risk Evaluation (SCORE) model. A pilot study.Frontiers in physiology · 2022Article
- Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke.Frontiers in aging neuroscience · 2022Review
- Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey.Cerebral circulation - cognition and behavior · 2022Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the association between serum level of C-reactive protein (CRP) and risk of cardiovascular events (CVEs) has been reported, the comprehensive assessment of the quantitative association of CRP level with risk of CVEs has not been reported. Our meta-analysis aims to quantitatively evaluate the association of CRP level and risk of CVEs. We searched PubMed and Embase databases for articles published up to December 6, 2019. Studies with data on men and women, different types of CVEs and multiple cohorts within a study were treated as independent studies. Generalized least-squares regression models were used to assess the quantitative association between CRP level and risk of CVEs. Restricted cubic splines were used to model the possible linear association between CRP and CVEs. We included 36 articles (60 studies; 227,715 participants) in the analysis. The pooled relative risks (RRs) of high versus low CRP level for cardiovascular disease (CVD), stroke and coronary heart disease (CHD) were 1.64 (95% confidence interval [CI], 1.49-1.82), 1.46 (95% CI, 1.35-1.58), and 1.55 (95% CI, 1.47-1.63), respectively. A linear association was found between CRP level and CVD (P = 0.429), stroke (P = 0.940), and CHD (P = 0.931); with each 1-mg/L increase in CRP level, the pooled RRs for CVD, stroke, and CHD were 1.18 (95% CI, 1.12-1.24), 1.07 (95% CI, 1.04-1.09), and 1.12 (95% CI, 1.08-1.16), respectively. This meta-analysis suggests that risk of CVEs increases with increasing serum CRP level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.