Evidence map›Paper›PMID 33980966›Full record

ArticleScientific reports2021

Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model.

Emanuela Locci, Alberto Chighine, Antonio Noto, Giulio Ferino, Alfonso Baldi, Dimitrios Varvarousis, Theodoros Xanthos, Fabio De-Giorgio, Matteo Stocchero, Ernesto d'Aloja

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Post Mortem Molecular Biomarkers of Asphyxia: A Literature Review.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Metabolomics investigation of post-mortem human pericardial fluid.International journal of legal medicine · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Emanuela LocciDepartment of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy. elocci@unica.it.ORCID 0000-0003-0237-4228
Alberto ChighineDepartment of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-0952-9712
Antonio NotoDepartment of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-3538-0050
Giulio FerinoDepartment of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.ORCID 0000-0002-6349-6491
Alfonso BaldiDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Caserta, Italy.ORCID 0000-0002-8693-3842
Dimitrios VarvarousisCardiology Department, Asklepeion Hospital, Athens, Greece.ORCID 0000-0003-4621-2095
Theodoros XanthosSchool of Medicine, European University Cyprus, Nicosia, Cyprus.ORCID 0000-0003-3670-9305
Fabio De-GiorgioDepartment of Health Care Surveillance and Bioethics, Section of Legal Medicine, Catholic University of Sacred Heart, Rome, Italy.ORCID 0000-0001-7433-0924
Matteo StoccheroDepartment of Women's and Children's Health, University of Padua, Padova, Italy.ORCID 0000-0001-9296-8390
Ernesto d'AlojaDepartment of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-4456-6252
University of Cagliari · ITEuropean University Cyprus · CYHippocration General Hospital · GRUniversità Cattolica del Sacro Cuore · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific markers, the differential diagnosis of primitive CA and CA secondary to asphyxiation relies on circumstantial details and on the pathologist experience, lacking objective evidence. Histological examination is currently considered the gold standard for CA post-mortem diagnosis. Here we present the comparative results of histopathology versus those previously obtained by

Indexed as

AnimalsAsphyxiaDisease Models, AnimalFemaleHistological TechniquesHumansMetabolomicsProton Magnetic Resonance SpectroscopySwine

Identifiers

PMID33980966
PMCPMC8115104
OpenAlexW3162036233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.