ArticleNature communications2021
Equilibrium and non-equilibrium furanose selection in the ribose isomerisation network.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 4 citations in OpenAlex.
- Redox chemistry of early Earth and the origin of life.Communications chemistry · 2026Review
- A Multidisciplinary Structural Approach to the Identification of theACS central science · 2024Article
- Chiral Recognition of D/L-Ribose by Visual and SERS Assessments.Molecules (Basel, Switzerland) · 2023Article
- Biological Catalysis and Information Storage Have Relied onBiomolecules · 2023Review
- ABC transporters are billion-year-old Maxwell Demons.Communications physics · 2023Article
- Article
- Anomeric Stereoauxiliary Cleavage of the C-N Bond of d-Glucosamine for the Preparation of Imidazo[1,5-a]pyridines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Allostery, and how to define and measure signal transduction.Biophysical chemistry · 2022Review
- Dissipation-Driven Selection under Finite Diffusion: Hints from Equilibrium and Separation of Time Scales.Entropy (Basel, Switzerland) · 2021Article
- Dissipation-driven selection of states in non-equilibrium chemical networks.Communications chemistry · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exclusive presence of β-D-ribofuranose in nucleic acids is still a conundrum in prebiotic chemistry, given that pyranose species are substantially more stable at equilibrium. However, a precise characterisation of the relative furanose/pyranose fraction at temperatures higher than about 50 °C is still lacking. Here, we employ a combination of NMR measurements and statistical mechanics modelling to predict a population inversion between furanose and pyranose at equilibrium at high temperatures. More importantly, we show that a steady temperature gradient may steer an open isomerisation network into a non-equilibrium steady state where furanose is boosted beyond the limits set by equilibrium thermodynamics. Moreover, we demonstrate that nonequilibrium selection of furanose is maximum at optimal dissipation, as gauged by the temperature gradient and energy barriers for isomerisation. The predicted optimum is compatible with temperature drops found in hydrothermal vents associated with extremely fresh lava flows on the seafloor.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.