Evidence map›Paper›PMID 33980656›Full record

ArticleJournal of medical ethics2022

Challenges to biobanking in LMICs during COVID-19: time to reconceptualise research ethics guidance for pandemics and public health emergencies?

Shenuka Singh, Rosemary Jean Cadigan, Keymanthri Moodley

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical ethics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Shenuka SinghFaculty of Medicine and Health Sciences, Centre for Medical Ethics and Law, Stellenbosch University, Cape Town, South Africa singhshen@ukzn.ac.za.ORCID 0000-0003-4842-602X
Rosemary Jean CadiganSocial Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-6793-2174
Keymanthri MoodleyFaculty of Medicine and Health Sciences, Centre for Medical Ethics and Law, University of Stellenbosch, Stellenbosch, Western Cape, South Africa.ORCID 0000-0003-3404-4901
Stellenbosch University · ZAUniversity of North Carolina at Chapel Hill · USWestern Cape Department of Health · ZA

Funding

Advancing Research Ethics Training in Southern Africa (ARESA): Leadership ProgramD43TW010511 · FIC · STELLENBOSCH UNIVERSITY · PI MOODLEY, KEYMANTHRI, RENNIE, STUART · 2017 to 2021
$1.2M
Community Engagement for H3Africa Biobanking Research: The Tygerberg ModelU01HG008222 · NHGRI · STELLENBOSCH UNIVERSITY · PI MOODLEY, KEYMANTHRI · 2015 to 2017
$205k
FIC NIH HHS D43 TW010511NHGRI NIH HHS U01 HG008222
6 · The paper itself

Abstract

Biobanking can promote valuable health research that may lead to significant societal benefits. However, collecting, storing and sharing human samples and data for research purposes present numerous ethical challenges. These challenges are exacerbated when the biobanking efforts aim to facilitate research on public health emergencies and include the sharing of samples and data between low/middle-income countries (LMICs) and high-income countries (HICs). In this article, we explore ethical challenges for COVID-19 biobanking, offering examples from two past infectious disease outbreaks in LMICs where biobanking activities contributed to the perpetuation of global inequities. We focus on how the ethical imperative to promote the common good during public health emergencies can conflict with protecting the interests of biobank participants. We discuss how conducting biobank research under a waiver of informed consent during public health emergencies is ethically permissible, provided guidance is in place to prevent biopiracy and exploitation of vulnerable communities. We also highlight the need for biobank collaborations between LMICs and HICs to promote capacity building and benefit sharing. Finally, we offer guidance to promote the ethical oversight of biobanks and biobank research during the COVID-19 pandemic or other future public health emergencies.

Indexed as

COVID-19Biological Specimen BanksDeveloping CountriesEmergenciesEthics, ResearchHumansPandemicsPublic Healthethicshuman tissuepublic health ethicsresearch ethics

Identifiers

PMID33980656
PMCPMC8117471
OpenAlexW3160716221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.