ReviewJournal of clinical microbiology2021
The Laboratory Diagnosis of Syphilis.
Review in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it, 207 citations in OpenAlex.
- Neurosyphilis-Induced Psychosis in Europe: A Systematic Review of Case Reports.Pathogens (Basel, Switzerland) · 2024Pooled it
- Solitary ulcer at the mons pubis in a heterosexual male patient.Wiener medizinische Wochenschrift (1946) · 2026Article
- Comparable treatment response rates with benzathine penicillin and doxycycline in early syphilis: evidence from a large German cohort.Infection · 2026Article
- The Congenital Syphilis Surge: Clinician Lessons to Turn the Rising Tide.Advances in pediatrics · 2026Review
- Incognito Standardized Patients to Assess Physician Awareness and Capacity to Recognize Primary Syphilis Presentation in Chinese STI Clinics.Sexually transmitted diseases · 2026Article
- Comparison of CDC and ECDC reverse sequence algorithms for syphilis diagnosis: clinical implications of discordant serological results.BMC infectious diseases · 2026Article
- Strengthening STD Screening Programs: Comprehensive Evaluation of High-Throughput Immunoassays for HIV and Syphilis Detection.Microorganisms · 2026Article
- Frequent emergency department utilization and syphilis case profiles in the Sentara healthcare system: a retrospective cross-sectional analysis in Hampton Roads.BMC public health · 2026Article
- Detection ofMicrobiology spectrum · 2026Article
- Treatment of Syphilis in Pregnancy and Congenital Syphilis: Current Evidence, Challenges, and Future Directions.Antibiotics (Basel, Switzerland) · 2026Review
- Updates on epidemiology and diagnostic tests of syphilis in South Korea.The Korean journal of internal medicine · 2026Review
- A pilot study: IncorporatingiScience · 2026Article
- Rapid visual detection of Treponema pallidum using the RPA-CRISPR/Cas12a system.Scientific reports · 2026Article
- Case Report: Congenital syphilis presenting with respiratory symptoms in an infant.Frontiers in pediatrics · 2026Article
- Diagnostic value of CSF CXCL8 combined with total protein for neurosyphilis: a logistic regression and ROC analysis.Frontiers in immunology · 2026Article
- Unexpected non-reactive nontreponemal serology in secondary syphilis: The prozone phenomenon and clinician-laboratory communication.Southern African journal of infectious diseases · 2026Article
- Epidemiological profile, completeness of notifications, and factors associated with the adequacy of treatment for syphilis during pregnancy: a cross-sectional study, Ubá, 2018-2023.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Assessment of the quality of notifications and investigations of congenital syphilis in Bahia, 2010-2021.Revista da Escola de Enfermagem da U S P · 2026Article
- Primary Oral Syphilis Presenting With Tongue Ulcers: A Case Report.Case reports in dentistry · 2026Article
- In-depth evaluation of false-positive biological reactions in the syphilis serological diagnosis: a cross-sectional study with two sampling components.Frontiers in cellular and infection microbiology · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis is a multisystem infection caused by the spirochete Treponema pallidum. Currently, cases of possible syphilis are commonly investigated using the treponemal serological tests T. pallidum IgG chemiluminescence immunoassay (CLIA) and the T. pallidum particle agglutination (TPPA). The nontreponemal rapid plasma reagin (RPR) flocculation test is used to assess disease activity. There has been a resurgence of syphilis diagnoses in Australia. Large foci of infection have been identified in isolated communities. The remoteness of these locations, in conjunction with the particular sociocultural characteristics of the population, pose unique challenges to the traditional diagnostic and treatment paradigms for syphilis. As a consequence of this increased incidence of syphilis, there has been interest in the utility of point-of-care tests (POCTs), nucleic acid amplification tests (NAATs), the role of IgM testing in suspected congenital syphilis, and the laboratory investigation of possible neurosyphilis. This review looks at the current status of traditional serological assays and provides an update on more recent methods. It assesses the published literature in this area and makes recommendations for the rational use of pathology testing to aid in the diagnosis of the many facets of syphilis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.