Evidence map›Paper›PMID 33980599›Full record

ArticleJournal of virology2021

The 5-HT

Marie Hagbom, Arash Hellysaz, Claudia Istrate, Johan Nordgren, Sumit Sharma, Felipe Meira de-Faria, Karl-Eric Magnusson, Lennart Svensson

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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  14. Tapping into 5-HTInternational journal of molecular sciences · 2021
    Review
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Marie HagbomDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Arash HellysazDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Claudia IstrateDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Johan NordgrenDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Sumit SharmaDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Felipe Meira de-FariaDivision of Surgery, Orthopedics and Oncology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Karl-Eric MagnussonDivision of Medical Microbiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Lennart SvenssonDivision of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotavirus infection is highly prevalent in children, and the most severe effects are diarrhea and vomiting. It is well accepted that the enteric nervous system (ENS) is activated and plays an important role, but knowledge of how rotavirus activates nerves within ENS and to the vomiting center is lacking. Serotonin is released during rotavirus infection, and antagonists to the serotonin receptor subtype 3 (5-HT

Indexed as

AnimalsDiarrheaEnteric Nervous SystemEnterochromaffin CellsGastrointestinal MotilityIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutReceptors, Serotonin, 5-HT3RotavirusRotavirus InfectionsSerotoninSerotonin 5-HT3 Receptor AntagonistsVomitingReceptors, Serotonin, 5-HT3SerotoninSerotonin 5-HT3 Receptor Antagonists5-HT3 receptordiarrheadisease mechanismsdisease symptomsmotilityrotavirusserotoninvomiting

Identifiers

PMID33980599
PMCPMC8274622
OpenAlexW3162301580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.