Evidence map›Paper›PMID 33980595›Full record

ArticleJournal of virology2021

MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter.

Marwa K Ibrahim, Tawfeek H Abdelhafez, Junko S Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El Kassas, Takanobu Kato and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
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  4. Kaempferol inhibits hepatitis B virus replicationFrontiers in cellular and infection microbiology · 2026
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Marwa K IbrahimDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Tawfeek H AbdelhafezDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Junko S TakeuchiDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Kosho WakaeDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Masaya SugiyamaGenome Medical Sciences Project, National Center for Global Health and Medicine, Ichikawa, Japan.
Masataka TsugeDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
Masahiko ItoDepartment of Virology and Parasitology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Koichi WatashiDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Mohamed El KassasEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Takanobu KatoDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Asako MurayamaDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Tetsuro SuzukiDepartment of Virology and Parasitology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kazuaki ChayamaCollaborative Research Laboratory of Medical Innovation, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kunitada ShimotohnoCenter for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Masamichi MuramatsuDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Hussein H AlyDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Takaji WakitaDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
National Institute of Infectious Diseases · JPHamamatsu University School of Medicine · JPHiroshima University · JPNational Center for Global Health and Medicine · JPHelwan University · EGMeiji University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) is a stealth virus that exhibits only minimal induction of the interferon system, which is required for both innate and adaptive immune responses. However, 90% of acutely infected adults can clear the virus, suggesting the presence of additional mechanisms that facilitate viral clearance. Here, we report that Maf bZIP transcription factor F (MafF) promotes host defense against infection with HBV. Using a small interfering RNA (siRNA) library and an HBV/NanoLuc (NL) reporter virus, we screened to identify anti-HBV host factors. Our data showed that silencing of

Indexed as

Cell Line, TumorCRISPR-Cas SystemsHepatitis B, ChronicHepatitis B virusHep G2 CellsHumansImmunity, InnateInterleukin-1betaMafF Transcription FactorNuclear ProteinsPromoter Regions, GeneticRNA InterferenceRNA, Small InterferingTranscription, GeneticTumor Necrosis Factor-alphaIL1B protein, humanInterleukin-1betaMAFF protein, humanMafF Transcription FactorNuclear ProteinsRNA, Small InterferingTNF protein, humanTumor Necrosis Factor-alphacytokineshepatitis B virusinflammationMafFrestriction factorstranscriptional repressionvirus-host interactions

Identifiers

PMID33980595
PMCPMC8274605
OpenAlexW3160901742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.