Evidence map›Paper›PMID 33980576›Full record

ArticleScience translational medicine2021

A portable magnetofluidic platform for detecting sexually transmitted infections and antimicrobial susceptibility.

Alexander Y Trick, Johan H Melendez, Fan-En Chen, Liben Chen, Annet Onzia, Aidah Zawedde, Edith Nakku-Joloba, Peter Kyambadde, Emmanuel Mande, Joshua Matovu and 8 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Point-of-care Tests for Chlamydia trachomatis and Neisseria gonorrhoeae: Review of the Literature.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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  4. Current and Emerging Approaches and Technologies for Rapid Detection of Neisseria gonorrhoeae Antimicrobial Resistance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Alexander Y TrickDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-3997-9669
Johan H MelendezDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Fan-En ChenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-6970-4370
Liben ChenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-0648-2456
Annet OnziaInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0002-6741-1512
Aidah ZaweddeInfectious Diseases Institute, Makerere University, Kampala, Uganda.
Edith Nakku-JolobaSchool of Public Health, Makerere University, Kampala, Uganda.
Peter KyambaddeAIDS Control Program, Division of Sexually Transmitted Infections, Ministry of Health, Kampala, Uganda.ORCID 0000-0002-9606-218X
Emmanuel MandeInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0003-0587-8181
Joshua MatovuInfectious Diseases Institute, Makerere University, Kampala, Uganda.
Maxine AtuheirweInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0002-2008-9896
Richard KwizeraInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID 0000-0002-5270-3539
Elizabeth A GilliamsDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1713-5107
Yu-Hsiang HsiehDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1616-8014
Charlotte A GaydosDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1021-3195
Yukari C ManabeDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Matthew M HamillDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1277-819X
Tza-Huei WangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. thwang@jhu.edu.ORCID 0000-0002-3540-9354
Johns Hopkins University · USInfectious Diseases Institute · UGMakerere University · UGMinistry of Health · UG

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Yukari C Manabe · 2007 to 2026
$34.6M
Technology development for point-of-care detection and antimicrobial susceptibility testing of Neisseria gonorrhoeaeR01AI138978 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WANG, TZA-HUEI JEFF · 2018 to 2021
$5.1M
Streamlined 15-min HIV Viral Load Self-Testing Using Finger-Stick BloodR61AI154628 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HSIEH, YU-HSIANG, MANABE, YUKARI C · 2020 to 2022
$1.4M
NIAID NIH HHS R01 AI138978NIAID NIH HHS R61 AI154628NIAID NIH HHS UM1 AI068613NIBIB NIH HHS U54 EB007958
6 · The paper itself

Abstract

Effective treatment of sexually transmitted infections (STIs) is limited by diagnostics that cannot deliver results rapidly while the patient is still in the clinic. The gold standard methods for identification of STIs are nucleic acid amplification tests (NAATs), which are too expensive for widespread use and have lengthy turnaround times. To address the need for fast and affordable diagnostics, we have developed a portable, rapid, on-cartridge magnetofluidic purification and testing (PROMPT) polymerase chain reaction (PCR) test. We show that it can detect

Indexed as

GonorrheaSexually Transmitted DiseasesBaltimoreHumansNeisseria gonorrhoeaeSensitivity and SpecificityUganda

Identifiers

PMID33980576
PMCPMC8363034
OpenAlexW3163506414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.