ArticleScience advances2021
Topological tuning of DNA mobility in entangled solutions of supercoiled plasmids.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Actively Induced Supercoiling Can Slow Down Plasmid Solutions by Trapping the Threading Entanglements.ACS nano · 2026Article
- Supercoils Stabilize a "DNA Corset" Condensate with Torsion-Dependent Hysteretic Compaction.JACS Au · 2026Article
- H2A.Z-nucleosomes are stabilized by the superhelicity-dependent DNA binding of the C-terminal tail of the histone variant.Nucleus (Austin, Tex.) · 2025Article
- VesicleVoyager: In Vivo Selection of Surface Displayed Proteins That Direct Extracellular Vesicles to Tissue-Specific Targets.Journal of extracellular vesicles · 2025Article
- Generation of topologically defined linear and cyclic DNA bottle brush polymersPolymer chemistry · 2025Article
- Co-initiating-system dual-mechanism drives the design of printable entangled polymer multinetworks.Nature communications · 2025Article
- Topological linking determines elasticity in limited valence networks.Nature materials · 2025Article
- Article
- Loops are geometric catalysts for DNA integration.Nucleic acids research · 2024Article
- From Bioreactor to Bulk Rheology: Achieving Scalable Production of Highly Concentrated Circular DNA.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Geometric learning of knot topology.Soft matter · 2023Article
- Cluster Formation in Solutions of Polyelectrolyte Rings.ACS nano · 2023Article
- To thread or not to thread? Effective potentials and threading interactions between asymmetric ring polymers.Soft matter · 2022Article
- Geometric Predictors of Knotted and Linked Arcs.ACS polymers Au · 2022Article
- Knot Factories with Helical Geometry Enhance Knotting and Induce Handedness to Knots.Polymers · 2022Article
- Optical-Tweezers-integrating-Differential-Dynamic-Microscopy maps the spatiotemporal propagation of nonlinear strains in polymer blends and composites.Nature communications · 2022Article
- Topological digestion drives time-varying rheology of entangled DNA fluids.Nature communications · 2022Article
- Tuning Protein Hydrogel Mechanics through Modulation of Nanoscale Unfolding and Entanglement in Postgelation Relaxation.ACS nano · 2022Article
- Review
- Influence of Environmental Parameters on the Stability of the DNA Molecule.Entropy (Basel, Switzerland) · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
Ring polymers in dense solutions are among the most intriguing problems in polymer physics. Because of its natural occurrence in circular form, DNA has been extensively used as a proxy to study the fundamental physics of ring polymers in different topological states. Yet, torsionally constrained-such as supercoiled-topologies have been largely neglected so far. The applicability of existing theoretical models to dense supercoiled DNA is thus unknown. Here, we address this gap by coupling large-scale molecular dynamics simulations with differential dynamic microscopy of entangled supercoiled DNA plasmids. We find that, unexpectedly, larger supercoiling increases the size of entangled plasmids and concomitantly induces an enhancement in DNA mobility. These findings are reconciled as due to supercoiling-driven asymmetric and double-folded plasmid conformations that reduce interplasmid entanglements and threadings. Our results suggest a way to topologically tune DNA mobility via supercoiling, thus enabling topological control over the (micro)rheology of DNA-based complex fluids.
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