ArticleScience advances2021
Common coding of expected value and value uncertainty memories in the prefrontal cortex and basal ganglia output.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Prefrontal cortex temporally multiplexes slow and fast dynamics in value learning and memory.Nature communications · 2025Article
- Spatial Processing Enhancement in the Prefrontal Cortex for Rapid Detection of Valuable Objects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Temporally and Functionally Distinct Contributions to Value Based Choice Along the Anterior-Posterior Dorsomedial Striatal Axis.bioRxiv : the preprint server for biology · 2025Article
- Robust memory of face moral values is encoded in the human caudate tail: a simultaneous EEG-fMRI study.Scientific reports · 2024Article
- Value-Based Search Efficiency Is Encoded in the Substantia Nigra Reticulata Firing Rate, Spiking Irregularity and Local Field Potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prefrontal cortex encodes value pop-out in visual search.iScience · 2023Article
- Sensorimotor-linked reward modulates smooth pursuit eye movements in monkeys.Frontiers in neuroscience · 2023Article
- Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia.Nature communications · 2022Article
- Stimulus presentation can enhance spiking irregularity across subcortical and cortical regions.PLoS computational biology · 2022Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent evidence implicates both basal ganglia and ventrolateral prefrontal cortex (vlPFC) in encoding value memories. However, comparative roles of cortical and basal nodes in value memory are not well understood. Here, single-unit recordings in vlPFC and substantia nigra reticulata (SNr), within macaque monkeys, revealed a larger value signal in SNr that was nevertheless correlated with and had a comparable onset to the vlPFC value signal. The value signal was maintained for many objects (>90) many weeks after reward learning and was resistant to extinction in both regions and to repetition suppression in vlPFC. Both regions showed comparable granularity in encoding expected value and value uncertainty, which was paralleled by enhanced gaze bias during free viewing. The value signal dynamics in SNr could be predicted by combining responses of vlPFC neurons according to their value preferences consistent with a scheme in which cortical neurons reached SNr via direct and indirect pathways.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.