ArticleScience advances2021
Functional interferometric diffusing wave spectroscopy of the human brain.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Compact FPGA-based software correlator for real-time blood flow measurement with diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- Monte Carlo simulations of time-resolved blood flow index: times-of-flight beyond ∼1 ns are necessary for brain-dominated measurements.Neurophotonics · 2026Article
- CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight.Neurophotonics · 2026Article
- Comparative validation of speckle contrast optical spectroscopy against diffuse correlation spectroscopy for monitoring human cerebral blood flow.Neurophotonics · 2026Article
- Highly parallel, 1060 nm interferometric diffusing wave spectroscopy with a time-of-flight filter.Biomedical optics express · 2026Article
- Assessing liquid light guides in diffuse correlation spectroscopy systems.Biomedical optics express · 2025Article
- Assessing human scalp and brain blood flow sensitivities via superficial temporal artery occlusion using speckle contrast optical spectroscopy.APL bioengineering · 2025Article
- Mapping human cerebral blood flow with high-density, multi-channel speckle contrast optical spectroscopy.Communications biology · 2025Article
- Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring.Neurophotonics · 2025Article
- Non-ergodicity and noise-corrected diffuse speckle contrast analysis in deep tissue blood flow measurement.Biomedical optics express · 2025Article
- Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy.Neurophotonics · 2025Article
- Optical, contact-free assessment of brain tissue stiffness and neurodegeneration.Biomedical optics express · 2025Article
- Portable six-channel laser speckle system for simultaneous measurement of cerebral blood flow and volume with potential applications in characterization of brain injury.Neurophotonics · 2025Article
- Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser device.Biomedical optics express · 2024Article
- Compact and cost-effective laser-powered speckle contrast optical spectroscopy fiber-free device for measuring cerebral blood flow.Journal of biomedical optics · 2024Article
- Measuring pulsatile cortical blood flow and volume during carotid endarterectomy.Biomedical optics express · 2024Article
- Article
- No-reflow after stroke reperfusion therapy: An emerging phenomenon to be explored.CNS neuroscience & therapeutics · 2024Review
- Article
- Diffuse Correlation Spectroscopy: A Review of Recent Advances in Parallelisation and Depth Discrimination Techniques.Sensors (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cerebral blood flow (CBF) is essential for brain function, and CBF-related signals can inform us about brain activity. Yet currently, high-end medical instrumentation is needed to perform a CBF measurement in adult humans. Here, we describe functional interferometric diffusing wave spectroscopy (fiDWS), which introduces and collects near-infrared light via the scalp, using inexpensive detector arrays to rapidly monitor coherent light fluctuations that encode brain blood flow index (BFI), a surrogate for CBF. Compared to other functional optical approaches, fiDWS measures BFI faster and deeper while also providing continuous wave absorption signals. Achieving clear pulsatile BFI waveforms at source-collector separations of 3.5 cm, we confirm that optical BFI, not absorption, shows a graded hypercapnic response consistent with human cerebrovascular physiology, and that BFI has a better contrast-to-noise ratio than absorption during brain activation. By providing high-throughput measurements of optical BFI at low cost, fiDWS will expand access to CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.